Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis (Articolo in rivista)

Type
Label
  • Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1164/ajrccm.158.6.9803014 (literal)
Alternative label
  • ANTONIO M. VIGNOLA, LOREDANA RICCOBONO, ANGELA MIRABELLA, MIRELLA PROFITA, PASCAL CHANEZ, VINCENZO BELLIA, GISÈLE MAUTINO, PROVVIDENZA D'ACCARDI, JEAN BOUSQUET, and GIOVANNI BONSIGNORE (1998)
    Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis
    in American journal of respiratory and critical care medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • ANTONIO M. VIGNOLA, LOREDANA RICCOBONO, ANGELA MIRABELLA, MIRELLA PROFITA, PASCAL CHANEZ, VINCENZO BELLIA, GISÈLE MAUTINO, PROVVIDENZA D'ACCARDI, JEAN BOUSQUET, and GIOVANNI BONSIGNORE (literal)
Pagina inizio
  • 1945 (literal)
Pagina fine
  • 1950 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • La rivista viene pubblicata anche on-line con ISSN 1073-449X (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 158 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Fisiopatologia Respiratoria, Consiglio Nazionale delle Ricerche, Palermo; Istituto di Medicina Generale e Pneumologia, Università di Palermo, Palermo, Italy; and Service des Maladies Respiratoires, INSERM, Montpellier, France (literal)
Titolo
  • Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis (literal)
Abstract
  • Asthma and chronic bronchitis are inflammatory diseases with extracellular matrix (ECM) remodeling and collagen deposition. Collagen homeostasis is controlled by metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). We evaluated MMP and TIMP balance in induced sputum of 10 control, 31 untreated asthmatic, and 16 chronic bronchitic subjects. We first performed zymographic analysis to identify the profile of MMPs. Zymography revealed a similar MMPs profile in all populations studied and that MMP-9 was the major enzyme released. We then measured, using enzyme immunoassay, the concentrations of MMP-9 and of its inhibitor TIMP-1 and evaluated whether airflow limitation may be associated with an imbalance between these enzymes. MMP-9 and TIMP-1 concentrations were greater in sputum of patients with asthma and chronic bronchitis than in control subjects. The molar ratio between MMP-9 and TIMP-1 was lower in asthmatics and chronic bronchitics than in control subjects, and positively correlated with FEV1 values. In asthma, MMP-9 levels were significantly correlated with the number of macrophages and neutrophils. This study shows that airway inflammation in asthma and chronic bronchitis is associated with an imbalance between MMP-9 and TIMP-1 which may have a role in the pathogenesis of ECM remodeling and airflow obstruction. (literal)
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