Optical isomer separation of potential analgesic drug candidates by using capillary electrophoresis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Optical isomer separation of potential analgesic drug candidates by using capillary electrophoresis (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/(SICI)1522-2683(19990801)20:12<2432::AID-ELPS2432>3.0.CO;2-B (literal)

Alternative label

• FERRARA G, SANTAGATI NA, ATURKI Z, FANALI S (1999)
  Optical isomer separation of potential analgesic drug candidates by using capillary electrophoresis
  in Electrophoresis (Weinh., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• FERRARA G, SANTAGATI NA, ATURKI Z, FANALI S (literal)

Pagina inizio

• 2432 (literal)

Pagina fine

• 2437 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• Electrophoresis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Catania; University of Catania; IMC-CNR; IMC-CNR (literal)

Titolo

• Optical isomer separation of potential analgesic drug candidates by using capillary electrophoresis (literal)

Abstract

• Using cyclodextrin capillary zone electrophoresis (CD-CZE), baseline separation of synthetic potential analgesic drug diastereoisomer candidates 6,11-dimethyl-1,2,3,4,5,6-hexahydro-3-[(2'-methoxycarbonyl-2'- phenylcyclopropyl)methyl]-2,6-methano-3-benzazocin-8-ol (MPCB) and 6,11- dimethyl-1,2,3,4,5,6-hexahydro-3-{[2'-methoxycarbonyl-2'(4- chlorophenyl)cyclopropyl]methyl}-2,6-methano-3-benzazocin-8-ol (CCB) was achieved. Among the cyclodextrins tested (hydroxypropyl-, carboxymethyl- and sulfobutyl-?-cyclodextrin (HP-?-CD, CM-?-CD and SBE-?-CD)) SBE-?-CD was found to be the most effective complexing agent, allowing good optical isomer separation. Resolution was also influenced by the CD concentration, pH of the buffer and presence of organic modifier in the background electrolyte. The optimum experimental conditions for the separation of studied analgesic drugs were found using 25 mM borate buffer at pH 9 containing 40 mM of SBE-?-CD and 20% v/v of methanol. Using the above-mentioned background electrolyte, it was also possible to separate, in the same run, the enantiomers of normetazocine (NMZ) as well as the optical isomers of (±)-cis-2- chloromethyl-1-phenyl cyclopropancarboxylic acid methyl ester (PCE) or (±)- cis-2-chloromethyl-1-(4-chlorophenyl)cyclopropancarboxylic acid methyl ester (CPCE) reagents used in the synthesis of the studied analgesic drugs). (literal)

Prodotto di

• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)
• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• ZEINEB ATURKI (Unità di personale interno)
• SALVATORE FANALI (Unità di personale interno)

Incoming links:

Autore CNR di

• ZEINEB ATURKI (Unità di personale interno)
• SALVATORE FANALI (Unità di personale interno)

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Electrophoresis (Rivista)