Quality control of benserazide-levodopa and carbidopa-levodopa tablets by capillary zone electrophoresis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Quality control of benserazide-levodopa and carbidopa-levodopa tablets by capillary zone electrophoresis (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Fanali S, Pucci V, Sabbioni C, Raggi MA (2000)
  Quality control of benserazide-levodopa and carbidopa-levodopa tablets by capillary zone electrophoresis
  in Electrophoresis (Weinh., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Fanali S, Pucci V, Sabbioni C, Raggi MA (literal)

Pagina inizio

• 2431 (literal)

Pagina fine

• 2437 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Electrophoresis (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IMC-CNR; University of Bologna; University of Bologna;University of Bologna;University of Bologna; (literal)

Titolo

• Quality control of benserazide-levodopa and carbidopa-levodopa tablets by capillary zone electrophoresis (literal)

Abstract

• In modern practice, the treatment of Parkinson's disease and syndrome is carried out using pharmaceutical formulations containing a combination of levodopa and a decarboxylation inhibitor (carbidopa or benserazide). Two pharmaceutical formulations were quantified by capillary zone electrophoresis using two procedures which differed only in the kind of background electrolyte used. One procedure used a 25 mM phosphate buffer, pH 2.5, while the second one used a 25 mM borate buffer, pH 8.5. The electrophoretic analysis was carried out using an uncoated fused- silica capillary, a separation voltage of 20 kV with currents typically less than 60 ?A, and spectrophotometric detection at 205 nm. Calibration curves were performed for levodopa (concentration range 1-100 ?g/mL), for carbidopa and benserazide (1-50 ?g/mL), and the plots of the peak area versus concentration were found to be linear with a correlation coefficient better than 0.9990. Satisfactory results were obtained when commercial tablets were analyzed in terms of accuracy (98-102%), repeatability (0.6-2.0%), and intermediate precision (1.1-2.6%). © WILEY-VCH Verlag GmbH, 2000. (literal)

Prodotto di

• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)
• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• SALVATORE FANALI (Persona)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)

Autore CNR di

• SALVATORE FANALI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Electrophoresis (Rivista)