Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase. (Articolo in rivista)

Type
Label
  • Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cirilli R., Ferretti R., Gallinella B., Turchetto L., Bolasco A., Secci D., Chimenti P., Pierini M., Fares V., Befani O., La Torre F. (2004)
    Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase.
    in Chirality (N.Y., N.Y. Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cirilli R., Ferretti R., Gallinella B., Turchetto L., Bolasco A., Secci D., Chimenti P., Pierini M., Fares V., Befani O., La Torre F. (literal)
Pagina inizio
  • 625 (literal)
Pagina fine
  • 636 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 16 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cirilli R. -Istituto Superiore di Sanità, Dip. del Farmaco, Rome, Italy Ferretti R. -Istituto Superiore di Sanità, Dip. del Farmaco, Rome, Italy Gallinella B. -Istituto Superiore di Sanità, Dip. del Farmaco, Rome, Italy Turchetto L. -Istituto Superiore di Sanità, Dip. del Farmaco, Rome, Italy Bolasco A. -Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma La Sapienza Secci D. -Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma La Sapienza Chimenti P. -Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma La Sapienza Pierini M. -Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma La Sapienza Fares V. -IC-CNR, Roma Befani O. -Dip. di Scienze Biochimiche A. Rossi Fanelli e Centro di Biologia Molecolare del CNR, Università degli Studi di Roma La Sapienza La Torre F. -Istituto Superiore di Sanità, Dip. del Farmaco, Rome, Italy (literal)
Titolo
  • Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase. (literal)
Abstract
  • The HPLC enantiomer separation of a novel series Of C-5-chiral 1-acetyl-3(4-hydroxy- and 2,4-dihydroxyphenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole derivatives, with inhibitory activity against monoamine oxidases (MAO) type A and B, was accomplished using polysaccharide-based chiral stationary phases (CSPs: Chiralpak AD, Chiralcel OD, and Chiralcel OJ). Pure alcohols, such as ethanol and 2-propanol, and typical normal-phase binary mixtures, such as n-hexane and alcohol modifier, were used as mobile phases. Single enantiomers of several analytes examinated were isolated on a semipreparative scale, and their chiroptical properties were measured. The assignment of the absolute configuration was established for one compound by single-crystal X-ray diffraction method and for the other three by CD spectroscopy. The inhibitory activity against MAO of racemic samples and single enantiomers were evaluated in vitro. (literal)
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