ARACHIDONIC-ACID, PROTEIN-KINASE-C ACTIVATORS AND BUD FORMATION IN HYDRA-VULGARIS (Articolo in rivista)

Type
Label
  • ARACHIDONIC-ACID, PROTEIN-KINASE-C ACTIVATORS AND BUD FORMATION IN HYDRA-VULGARIS (Articolo in rivista) (literal)
Anno
  • 1993-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/0742-8413(93)90198-T (literal)
Alternative label
  • De Petrocellis L, Di Marzo V, Gianfrani C, Minei R (1993)
    ARACHIDONIC-ACID, PROTEIN-KINASE-C ACTIVATORS AND BUD FORMATION IN HYDRA-VULGARIS
    in Comparative biochemistry and physiology. C. Comparative pharmacology and toxicology; Pergamon-Elsevier Science Ltd., Oxford (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Petrocellis L, Di Marzo V, Gianfrani C, Minei R (literal)
Pagina inizio
  • 219 (literal)
Pagina fine
  • 224 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 105 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. CNR, IST CIBERNETICA, VIA TOIANO 6, I-80072 ARCO FELICE, NAPLES, ITALY 2. CNR,IST CHIM MOLEC INTERESSE BIOL, I-80072 NAPLES, ITALY (literal)
Titolo
  • ARACHIDONIC-ACID, PROTEIN-KINASE-C ACTIVATORS AND BUD FORMATION IN HYDRA-VULGARIS (literal)
Abstract
  • 1. The effect of the protein kinase C (PKC) activators verrucosin B (VB), 1,2-sn-dioctanoylglycerol (diC8) and phorbol-12-myristate-13-acetate (PMA), of arachidonic acid (AA) and of substances interfering with its release, re-uptake and metabolism was studied in Hydra vulgaris. 2. All PKC activators potently inhibited bud formation, VB and PMA being 10,000 x more potent than diC8. VB effect was maximal already after 10 min incubation with hydra and persisted at 24 hr incubations. 3. AA and substances inhibiting its re-uptake from cell membrane or its metabolism also inhibited bud formation, whereas oleyl-oxyethyl-phosphorylcholine (OOPC), an inhibitor of phospholipase A2, potently induced bud formation. 4. The findings described herein suggest a role for both PKC activation and AA in the inhibition of bud formation in H. vulgaris. (literal)
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