http://www.cnr.it/ontology/cnr/individuo/prodotto/ID197006

Novel diterpenoid diacylglycerols from marine molluscs: Potent morphogens and protein kinase C activators (Articolo in rivista)

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Novel diterpenoid diacylglycerols from marine molluscs: Potent morphogens and protein kinase C activators (Articolo in rivista) (literal)

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De Petrocellis L, Orlando P, Gavagnin M, Ventriglia M, Cimino G, Di Marzo V. (1996)
Novel diterpenoid diacylglycerols from marine molluscs: Potent morphogens and protein kinase C activators
in Experientia; Birkhäuser, Basel (Swaziland)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

De Petrocellis L, Orlando P, Gavagnin M, Ventriglia M, Cimino G, Di Marzo V. (literal)

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Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. CNR,IST CIBERNETICA, I-80072 ARCO FELICE, NAPOLI, ITALY 2. CNR, IST CHIM MOL INTERESSE BIOL, I-80072 ARCO, NAPOLI, ITALY 3. CNR,IST BIOCHIM PROT & ENZIMOL,I-80072 ARCO,NAPOLI,ITALY 4. UNIV NAPLES,FAC FARM,DIPARTIMENTO CHIM FARMACEUT & TOSSICOL,NAPLES,ITALY (literal)

Titolo

Novel diterpenoid diacylglycerols from marine molluscs: Potent morphogens and protein kinase C activators (literal)

Abstract

Five novel 1,2-sn-diacylglycerols with diterpenoid acyl moieties in the sn-1 position were isolated and characterized, together with the corresponding 1,3-sn-diacylglycerols, from three species of dorid nudibranchs molluscs. Their potent activity as morphogens in vivo in the Hydra tentacle regeneration assay and their parallel activity as activators of rat brain protein kinase C (PKC) in vitro are reported here. Our findings promote the use of these compounds as useful molecular probes for both in vivo and in vitro studies on the participation of PKC in cell development. (literal)

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