Metabolism of anandamide and 2-arachidonoylglycerol: An historical overview and some recent developments (Articolo in rivista)

Type
Label
  • Metabolism of anandamide and 2-arachidonoylglycerol: An historical overview and some recent developments (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Di Marzo V, De Petrocellis L, Bisogno T, Melck D. (1999)
    Metabolism of anandamide and 2-arachidonoylglycerol: An historical overview and some recent developments
    in Lipids; American oil chemists' society, Champaign, Il. (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Di Marzo V, De Petrocellis L, Bisogno T, Melck D. (literal)
Pagina inizio
  • S319 (literal)
Pagina fine
  • S325 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 34 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • . CNR, Ist Chim Mol Interesse Biol, Natl Inst Chem Biol Syst, I-80072 Arco Felice, Napoli, Italy 2. CNR, Ist Cibernetica, I-80072 Arco Felice, Napoli, Italy (literal)
Titolo
  • Metabolism of anandamide and 2-arachidonoylglycerol: An historical overview and some recent developments (literal)
Abstract
  • Anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol are the two endogenous agonists of cannabinoid receptors discovered to date. Like other eicosanoids, and unlike classical neuromodulators, these two compounds are synthesized by neurons on demand, i.e., their biosynthesis, rather than release, is stimulated by Ca2+ influx and cell membrane depolarization. Both endocannabinoids can be produced from membrane phosphoglycerides through the action of phospholipases, although de novo pathways have also been suggested. Once released by cells, the action of both anandamide and 2-arachidonoylglycerol is terminated-after their diffusion through the cell membrane-by the hydrolysis of the amide or ester bonds to yield arachidonic acid, which is then immediately reincorporated into phospholipids. One enzyme, fatty acid amide hydrolase, catalyzes the hydrolysis of both endocannabinoids in nervous and nonnervous cells. This enzyme also recognizes N-palmitoylethanolamine, an antiinflammatory congener of anandamide, with a catalytic efficiency that depends on the cell type under study. However, the existence of different isozymes with different affinity far anandamide and N-palmitoylethanolamine has not been investigated. Moreover, little work has been performed on the regulation of anandamide formation and breakdown, and several open questions remain as to the possible biosynthetic and degradative mechanisms of cannabimimetic 2-arachidonoylglycerol in nucleated blood cells such as macrophages. Finally, the co-existence of both endocannabinoids in invertebrates has not been fully established. Here we briefly review the slate of the art, and present new data from our laboratory, on these four largely unexplored aspects of endacannabinoid metabolism. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it