Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (Articolo in rivista)

Type
Label
  • Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1164/ajrccm.157.2.9703070 (literal)
Alternative label
  • ANTONIO M. VIGNOLA, ANNA BONANNO, ANGELA MIRABELLA, LOREDANA RICCOBONO, FRANCO MIRABELLA, MIRELLA PROFITA, VINCENZO BELLIA, JEAN BOUSQUET, and GIOVANNI BONSIGNORE (1998)
    Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients
    in American journal of respiratory and critical care medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • ANTONIO M. VIGNOLA, ANNA BONANNO, ANGELA MIRABELLA, LOREDANA RICCOBONO, FRANCO MIRABELLA, MIRELLA PROFITA, VINCENZO BELLIA, JEAN BOUSQUET, and GIOVANNI BONSIGNORE (literal)
Pagina inizio
  • 505 (literal)
Pagina fine
  • 511 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • La rivista viene pubblicata anche on-line con ISSN 1073-449X (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 157 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Fisiopatologia Respiratoria, Consiglio Nazionale delle Ricerche and Istituto di Medicina Generale e Pneumologia, Università di Palermo, Palermo, Italy; and Departement des Maladies Respiratoires Unit 454 INSERM, Montpellier, France (literal)
Titolo
  • Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (literal)
Abstract
  • Asthma and chronic bronchitis are inflammatory diseases associated with remodeling of the extracellular matrix (ECM). Elastin, a major component of the ECM in the airways, has been previously found to be disrupted in asthma and chronic bronchitis. This study was aimed at evaluating whether elastin disruption might be associated with an imbalance between elastase (active and total) and a1-proteinase inhibitor ( a1-PI), the main inhibitor of elastase. We measured elastase and a1-PI in induced sputum obtained from 16 control subjects, 10 healthy smokers, 19 asthmatic patients, and 10 chronic bronchitis patients. We also assessed the possible origin of elastase, evaluating its levels in sputum with reference to differential cell counts. We found that in induced sputum obtained from asthmatic and chronic bronchitis patients, the levels of both total and active elastase were significantly increased as compared with those of control subjects and healthy smokers and were significantly correlated with the percentage of neutrophils. In addition, in asthma and chronic bronchitis patients, the levels of active and total elastase were inversely correlated with the degree of airway obstruction as assessed from FEV1 values. This study shows that airway inflammation in asthma and chronic bronchitis is associated with high levels of active elastase, which may play a role in the pathogenesis of airway remodeling. (literal)
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