http://www.cnr.it/ontology/cnr/individuo/prodotto/ID196944
Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (Articolo in rivista)
- Type
- Label
- Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (Articolo in rivista) (literal)
- Anno
- 1998-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1164/ajrccm.157.2.9703070 (literal)
- Alternative label
ANTONIO M. VIGNOLA, ANNA BONANNO, ANGELA MIRABELLA, LOREDANA RICCOBONO,
FRANCO MIRABELLA, MIRELLA PROFITA, VINCENZO BELLIA, JEAN BOUSQUET,
and GIOVANNI BONSIGNORE (1998)
Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients
in American journal of respiratory and critical care medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- ANTONIO M. VIGNOLA, ANNA BONANNO, ANGELA MIRABELLA, LOREDANA RICCOBONO,
FRANCO MIRABELLA, MIRELLA PROFITA, VINCENZO BELLIA, JEAN BOUSQUET,
and GIOVANNI BONSIGNORE (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- La rivista viene pubblicata anche on-line con ISSN 1073-449X (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Fisiopatologia Respiratoria, Consiglio Nazionale delle Ricerche and
Istituto di Medicina Generale e Pneumologia, Università di Palermo, Palermo, Italy; and
Departement des Maladies Respiratoires Unit 454 INSERM, Montpellier, France (literal)
- Titolo
- Increased Levels of Elastase and alfa1-Antitrypsin in Sputum of Asthmatic Patients (literal)
- Abstract
- Asthma and chronic bronchitis are inflammatory diseases associated with remodeling of the extracellular
matrix (ECM). Elastin, a major component of the ECM in the airways, has been previously found
to be disrupted in asthma and chronic bronchitis. This study was aimed at evaluating whether elastin
disruption might be associated with an imbalance between elastase (active and total) and
a1-proteinase
inhibitor (
a1-PI), the main inhibitor of elastase. We measured elastase and
a1-PI in induced sputum
obtained from 16 control subjects, 10 healthy smokers, 19 asthmatic patients, and 10 chronic
bronchitis patients. We also assessed the possible origin of elastase, evaluating its levels in sputum
with reference to differential cell counts. We found that in induced sputum obtained from asthmatic
and chronic bronchitis patients, the levels of both total and active elastase were significantly increased
as compared with those of control subjects and healthy smokers and were significantly correlated
with the percentage of neutrophils. In addition, in asthma and chronic bronchitis patients, the
levels of active and total elastase were inversely correlated with the degree of airway obstruction as
assessed from FEV1 values. This study shows that airway inflammation in asthma and chronic bronchitis
is associated with high levels of active elastase, which may play a role in the pathogenesis of airway
remodeling. (literal)
- Prodotto di
- Autore CNR
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