Effect of body weight on the volume of distribution of theophylline (Articolo in rivista)

Type
Label
  • Effect of body weight on the volume of distribution of theophylline (Articolo in rivista) (literal)
Anno
  • 1988-01-01T00:00:00+01:00 (literal)
Alternative label
  • 1 Rizzo A, 2 Mirabella A, 3 Bonanno A (1988)
    Effect of body weight on the volume of distribution of theophylline
    in Lung (N.Y.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1 Rizzo A, 2 Mirabella A, 3 Bonanno A (literal)
Pagina inizio
  • 269 (literal)
Pagina fine
  • 276 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 166 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • ubme (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Servizio di Fisiopatologia Respiratoria USL 60, Palermo 2 Istituto di Medicina Generale e Pneumologia, Università di Palermo 3 Istituto di Fisiopatologia Respiratoria CNR Palermo (literal)
Titolo
  • Effect of body weight on the volume of distribution of theophylline (literal)
Abstract
  • The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW). In obese subjects it has been suggested that lean or ideal body weight (IBW) is the best predictor. In a sample of 40 acutely ill asthmatic patients (aged 22 to 78 yr, weighing 45 to 176 kg) we measured Vd and found that (1) it increases with TBW, (2) it cannot be accurately pre- dicted from either TBW or IBW alone by a simple regression analysis. Power functions have been usefully applied in comparing the pharmaco- kinetics of animal species, including humans, with different body mass. In our sample, data were best fitted by the equation Vd = 1.29 TBW °74, which seems to take care of lean as well as obese patients. Results were confirmed (r = 0.89 between predicted and measured values) in a second independent sample of patients (aged 26 to 77 yr, weighing 38 to 167 kg). This helps to minimize the error in obtaining the target serum concentration of theophyl- line when giving a LD calculated from a predicted Vd value. (literal)
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