Urinary leukotriene E4 in the assessment of nocturnal asthma (Articolo in rivista)

Type
Label
  • Urinary leukotriene E4 in the assessment of nocturnal asthma (Articolo in rivista) (literal)
Anno
  • 1996-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bellia V, Bonanno A, Cibella F, Cuttitta G, Mirabella A, Profita M, Vignola AM, Bonsignore G (1996)
    Urinary leukotriene E4 in the assessment of nocturnal asthma
    in Journal of allergy and clinical immunology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bellia V, Bonanno A, Cibella F, Cuttitta G, Mirabella A, Profita M, Vignola AM, Bonsignore G (literal)
Pagina inizio
  • 735 (literal)
Pagina fine
  • 741 (literal)
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  • 97 (literal)
Rivista
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  • 7 (literal)
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  • 3 (literal)
Note
  • PubMe (literal)
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  • Clinica Pneumologica dell'Università, Palermo Consiglio Nazionale delle Ricerche, Istituto di Fisiopatologia Respiratoria, Palermo (literal)
Titolo
  • Urinary leukotriene E4 in the assessment of nocturnal asthma (literal)
Abstract
  • BACKGROUND: Urinary leukotriene E4 (LTE4) is a marker of the body's production of cysteinyl LTs, important mediators of airway inflammation. The role of the latter in nocturnal asthma is a topic of increasing interest. OBJECTIVE: This investigation was aimed at determining whether nighttime attacks are associated with increased release of LTs, expressed by urinary LTE4, and the relationship between the two phenomena. METHODS: Three groups were studied: group A, seven control subjects; group B, nine asthmatic patients without nocturnal attacks; and group C, nine asthmatic patients with a comparable daytime FEV1 but who were experiencing nocturnal exacerbations (morning dips in peak expiratory flow greater than 20%). Urine was collected over 24 hours in three samples (9:00 AM to 3:00 PM; 3:00 PM to 9:00 PM; and 9:00 PM to 9:00 AM). LTE4 was measured by high-performance liquid chromatography and radioimmunoassay and expressed as nanograms per millimole of creatinine. RESULTS: No significant differences between urinary LTE4 were noticed within groups A and B. Conversely, in group C urinary LTE4 at night (geometric mean with 95% confidence interval; 35.16 with 28.77-42.85) was significantly higher than that of the other samples (respectively 23.12 with 17.78-30.06, p less than 0.05; and 25.18 with 21.03-30.13, p less than 0.02); it was also significantly higher than in all the samples of other groups. A significant (p less than 0.02) linear correlation was observed between morning dip in peak expiratory flow and the log urinary LTE4 in the nocturnal sample. CONCLUSION: These results indicate the role of LTs in nocturnal asthma and suggest that urinary LTE4 may be a useful marker of this condition (literal)
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