Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jm0708578 (literal)

Alternative label

• Mura P., Camalli M., Bindoli A., Sorrentino F., Casini A., Gabbiani C., Corsini M., Zanello P., Rigobello MP., Messori L. (2007)
  Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound.
  in Journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mura P., Camalli M., Bindoli A., Sorrentino F., Casini A., Gabbiani C., Corsini M., Zanello P., Rigobello MP., Messori L. (literal)

Pagina inizio

• 5871 (literal)

Pagina fine

• 5874 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Mura P. - IC-CNR, Roma Camalli M. -IC-CNR,Roma Bindoli A. -IN_CNR, Padova Sorrentino F. -Dipartimento di Chimica Biologica, Università degli Studi di Padova Casini A. -Department of Chemistry, University of Florence Gabbiani C. -Department of Chemistry, University of Florence Corsini M. -Department of Chemistry, University of Siena Zanello P. -Department of Chemistry, University of Siena Rigobello MP. -Dipartimento di Chimica Biologica, Università degli Studi di Padova Messori L. -Department of Chemistry, University of Florence (literal)

Titolo

• Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (literal)

Abstract

• A novel \"Keppler type\" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound. (literal)

Prodotto di

• Studi strutturali e funzionali di acidi nucleici (PM.P06.001.002) (Modulo)
• Institute of Crystallography (IC) (Istituto)

Autore CNR

• MERCEDES CAMALLI (Unità di personale interno)
• PASQUALE MURA (Unità di personale interno)
• ALBERTO BINDOLI (Unità di personale interno)

Incoming links:

Autore CNR di

• ALBERTO BINDOLI (Unità di personale interno)
• PASQUALE MURA (Unità di personale interno)
• MERCEDES CAMALLI (Unità di personale interno)

Prodotto

• Institute of Crystallography (IC) (Istituto)
• Studi strutturali e funzionali di acidi nucleici (PM.P06.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)