Effect of ageing on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Effect of ageing on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma (Articolo in rivista) (literal)

Anno

• 1997-01-01T00:00:00+01:00 (literal)

Alternative label

• Bellia V, Cuttitta G, Cibella F, Vignola AM, Crescimanno G, D'Accardi P, Catalano F, Bonsignore G (1997)
  Effect of ageing on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma
  in The European respiratory journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bellia V, Cuttitta G, Cibella F, Vignola AM, Crescimanno G, D'Accardi P, Catalano F, Bonsignore G (literal)

Pagina inizio

• 1803 (literal)

Pagina fine

• 1808 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 10 (literal)

Rivista

• ?The ?European respiratory journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Clinica Pneumologica dell'Università, Palermo Consiglio Nazionale delle Ricerche, Istituto di Fisiopatologia Respiratoria, Palermo (literal)

Titolo

• Effect of ageing on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma (literal)

Abstract

• The aim of this study was to evaluate the role of ageing on variability of airflow obstruction and on the specific pattern of nocturnal exacerbations (\"morning dipping\" of peak expiratory flow (PEF)) in asthma. Two groups of stable asthmatics (Group A: 23 patients, aged 14-47 yrs; Group B: 20 patients, aged 53-74 yrs), that were similar for duration of disease, degree of obstruction and response to bronchodilators, were studied. PEF was monitored four times daily for 2 weeks, and amplitude of variation and \"morning dip\" were calculated. Both PEF amplitude and \"morning dip\" were greater in the older patients (p<0.005). Amplitude was negatively correlated with baseline forced expiratory volume in one second (FEV1) in both groups (p<0.01); multiple correlation with age, duration of disease, baseline FEV1 and degree of reversibility was significant in the older group only. Morning dip was inversely correlated to baseline FEV1 (p<0.01) and reversibility (p<0.05). Nocturnal symptoms were reported by all of the five Group A \"dippers\", but by only 6 of the 13 Group B \"dippers\" (p<0.04). Ageing contributes to increased variability of airway calibre in asthma. Aged patients are potentially at risk because functional evidence of nocturnal asthma may frequently be accompanied by a poor subjective awareness. Therefore, a more extensive practice of PEF monitoring is recommended in aged asthmatics (literal)

Prodotto di

• Epidemiologia delle broncopneumopatie e di altre malattie croniche non comunicabili (ME.P01.014.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• GRAZIA CRESCIMANNO (Unità di personale interno)
• GIUSEPPINA CUTTITTA (Persona)
• FABIO CIBELLA (Persona)

Incoming links:

Autore CNR di

• GRAZIA CRESCIMANNO (Unità di personale interno)
• GIUSEPPINA CUTTITTA (Persona)
• FABIO CIBELLA (Persona)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Epidemiologia delle broncopneumopatie e di altre malattie croniche non comunicabili (ME.P01.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?European respiratory journal (Rivista)