http://www.cnr.it/ontology/cnr/individuo/prodotto/ID196182
Two anti-microtubular drugs for two differential responses : a rice cell line resistant to EPC remains susceptible to oryzalin (Articolo in rivista)
- Type
- Label
- Two anti-microtubular drugs for two differential responses : a rice cell line resistant to EPC remains susceptible to oryzalin (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Stefano Morettini
Silvia Gianì
Peter Nick
Laura Morello
Diego Breviario (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto Biologia e Biotecnologia Agraria CNR Milano Italy
Molecular Cell Biology Botanical Institute Karlsruhe Institute of Technology , Karlsruhe Germany (literal)
- Titolo
- Two anti-microtubular drugs for two differential responses : a rice cell line resistant to EPC remains susceptible to oryzalin (literal)
- Abstract
- Sensitivity to the two anti-microtubular drugs oryzalin and EPC (ethyl-N-phenylcarbamate) is shown to
be uncoupled in the rice EPC-resistant ER31d cell line, derived from the corresponding ER31 mutant. The
ER31d cell line grows in the presence of EPC but it remains susceptible to oryzalin. In the presence of
concentrations of EPC up to 0.4 mM, ER31d cells remain viable maintaining cell anisotropy and
detectable cortical microtubule array. The amount of alpha- and beta-tubulin is also maintained high through
a regulatory mechanism that operates at post-transcriptional level. In contrast, all these cellular and
molecular parameters are heavily affected by the addition of 1 mM oryzalin. Also, the pattern of posttranslationally
modified alpha-tubulins changes in the ER31d cells compared to that of their Nihon-Masari
wild type line of reference. The different response elicited by the two herbicides is discussed in relation
to a possible differential sensitivity of the cortical MT array, that may in turn relate to their different
tubulin-binding specificities and chemical structure. (literal)
- Prodotto di
- Autore CNR
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