http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19543
Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti- (Articolo in rivista)
- Type
- Label
- Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti- (Articolo in rivista) (literal)
- Anno
- 2001-01-01T00:00:00+01:00 (literal)
- Alternative label
Covaceuszach S., Cattaneo A., Lamba D. (2001)
Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti-
in Acta crystallographica. Section D, Biological crystallography.
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Covaceuszach S., Cattaneo A., Lamba D. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Covaceuszach S.: SISSA, Trieste
Cattaneo A.: SISSA, Trieste
Lamba D.: IC-CNR, Trieste (literal)
- Titolo
- Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti- (literal)
- Abstract
- The monoclonal antibody MNAC13 is a potent antagonist that prevents the binding of nerve-growth factor (NGF) to its tyrosine kinase A receptor (TrkA) in a variety of systems. Structural studies of the FabMNAC13 fragment were performed to gain insights into the mechanism of action of this potentially therapeutic monoclonal antibody. The optimal conditions for crystallization of FabMNAC13 were determined. Crystals appeared as prismatic bundles, displayed P212121 space-group symmetry and diffracted to a resolution of 1.8 Å. The unit-cell parameters were determined to be a = 52.73, b = 67.55, c = 111.43 Å. The data set was 99.5% complete. Molecular replacement was performed, resulting in a correlation coefficient of 0.55 and an R value of 0.40. The structure refinement is now in progress. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi