Haplotype affinities resolve a major component of goat (Capra hircus) MtDNA D-loop diversity and reveal specific features of the Sardinian stock. (Articolo in rivista)

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  • Haplotype affinities resolve a major component of goat (Capra hircus) MtDNA D-loop diversity and reveal specific features of the Sardinian stock. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Daniela Piras1#, Maria Grazia Doro1#, Giuseppina Casu1, Paola Maria Melis1, Simona Vaccargiu1, Ignazio Piras2, Debora Parracciani3, Roberta Stradoni3, Bruno Frongia3, Graziano Lai3, Salvatore Sale4, Walter Cattari4, Roberto Piras4, Ombretta Querci4, Piergiorgio Demuro4, Sandro Cui4, Franco Atzori4, Marco Mancosu4, Francesca Marchiori4, Rossana Cammelli4, Alessandra Spiga4, Pier Paolo Loddo4, Gianfranco Pili4, Roberto Boi4, Giuseppe Argiolas4, Paolo Mereu5, Giovanni Giuseppe Leoni6, Salvatore Naitana6, Mario Pirastu1,3, Andrea Novelletto7* (2012)
    Haplotype affinities resolve a major component of goat (Capra hircus) MtDNA D-loop diversity and reveal specific features of the Sardinian stock.
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daniela Piras1#, Maria Grazia Doro1#, Giuseppina Casu1, Paola Maria Melis1, Simona Vaccargiu1, Ignazio Piras2, Debora Parracciani3, Roberta Stradoni3, Bruno Frongia3, Graziano Lai3, Salvatore Sale4, Walter Cattari4, Roberto Piras4, Ombretta Querci4, Piergiorgio Demuro4, Sandro Cui4, Franco Atzori4, Marco Mancosu4, Francesca Marchiori4, Rossana Cammelli4, Alessandra Spiga4, Pier Paolo Loddo4, Gianfranco Pili4, Roberto Boi4, Giuseppe Argiolas4, Paolo Mereu5, Giovanni Giuseppe Leoni6, Salvatore Naitana6, Mario Pirastu1,3, Andrea Novelletto7* (literal)
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  • 7 (literal)
Rivista
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  • 2 (literal)
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  • 1 Institute of Population Genetics, National Research Council, Sassari, Italy, 2 Shardna Life Sciences, Cagliari, Italy, 3 Genetic Park of Ogliastra, Perdasdefogu, Italy, 4 ARAS, Regional Association of Sardinian Farmers, Cagliari, Italy, 5 Department of Physiological, Biochemical and Cell Sciences, University of Sassari, Sassari, Italy, 6 Faculty of Veterinary Sciences, University of Sassari, Sassari, Italy, 7 Department of Biology, University \"Tor Vergata\", Rome, Italy (literal)
Titolo
  • Haplotype affinities resolve a major component of goat (Capra hircus) MtDNA D-loop diversity and reveal specific features of the Sardinian stock. (literal)
Abstract
  • Goat mtDNA haplogroup A is a poorly resolved lineage absorbing most of the overall diversity and is found in locations as distant as Eastern Asia and Southern Africa. Its phylogenetic dissection would cast light on an important portion of the spread of goat breeding. The aims of this work were 1) to provide an operational definition of meaningful mtDNA units within haplogroup A, 2) to investigate the mechanisms underlying the maintenance of diversity by considering the modes of selection operated by breeders and 3) to identify the peculiarities of Sardinian mtDNA types. We sequenced the mtDNA D-loop in a large sample of animals (1,591) which represents a non-trivial quota of the entire goat population of Sardinia. We found that Sardinia mirrors a large quota of mtDNA diversity of Western Eurasia in the number of variable sites, their mutational pattern and allele frequency. By using bayesian analysis, a distance-based tree and a network analysis, we recognized demographically coherent groups of sequences identified by particular subsets of the variable positions. The results showed that this assignment system could be reproduced in other studies, capturing the greatest part of haplotype diversity.We identified haplotype groups overrepresented in Sardinian goats as a result of founder effects. We found that breeders maintain diversity of matrilines most likely through equalization of the reproductive potential. Moreover, the relevant amount of inter-farm mtDNA diversity found does not increase proportionally with distance. Our results illustrate the effects of breeding practices on the composition of maternal gene pool and identify mtDNA types that may be considered in projects aimed at retrieving the maternal component of the oldest breeds of Sardinia. (literal)
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