Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/chem.201103318 (literal)

Alternative label

• C. Nativi, O. Francesconi, G. Gabrielli, I. De Simone, B. Turchetti, T. Mello, L. Di Cesare Mannelli, C. Ghelardini, P. Buzzini, S. Roelens (2012)
  Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts
  in Chemistry - A European Journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• C. Nativi, O. Francesconi, G. Gabrielli, I. De Simone, B. Turchetti, T. Mello, L. Di Cesare Mannelli, C. Ghelardini, P. Buzzini, S. Roelens (literal)

Pagina inizio

• 5064 (literal)

Pagina fine

• 5072 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 18 (literal)

Rivista

• Chemistry - A European Journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 16 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Chimica, Università di Firenze; Dipartimento di Biologia Applicata and Industrial Yeasts Collection DBVPG, Università di Perugia; Dipartimento di Fisiopatologia Clinica, Università di Firenze; Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze; Istituto di Metodologie Chimiche (IMC) Consiglio Nazionale delle Ricerche (CNR). (literal)

Titolo

• Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts (literal)

Abstract

• The biological activity of a set of structurally related aminopyrrolic synthetic receptors for monosaccharides has been tested vs. yeast and yeast-like microorganisms and compared to their binding affinity toward mannosides. Antibiotic activity comparable to that of well-known polyene (amphotericin B) or azole (ketoconazole) drugs has been found for some members of the family, along with a general correlation with binding abilities. A systematic structure-activity-affinity investigation shed light on the structural and functional requirements necessary for antibiotic activity and identified the tripodal 1 as the most potent compound of the set. Together with toxicity tests and inhibitor localization experiments performed through fluorescence microscopy, these studies lead to the characterization of a new class of carbohydrate binding agents possessing antibiotic activity, in which pyrrolic groups precisely structured on a tripodal architecture appear to be responsible for permeability through the cell wall of pathogens, as well as for antibiotic activity inside the cytoplasm (literal)

Prodotto di

• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• STEFANO ROELENS (Persona)

Insieme di parole chiave

• Parole chiave di "Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• http://www.cnr.it/ontology/cnr/individuo/modulo/ID6999

Autore CNR di

• STEFANO ROELENS (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chemistry - A European Journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity vs. Pathogenic Yeasts" (Insieme di parole chiave)