http://www.cnr.it/ontology/cnr/individuo/prodotto/ID195107
Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate (Articolo in rivista)
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- Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate (Articolo in rivista) (literal)
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- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.mrgentox.2012.03.013 (literal)
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Zeni O 1; Sannino A 1,2; Romeo S 1,3; Massa R 1,4; Sarti M 1; Reddy AB 5; Prihoda TJ 6; Vijayalaxmi 5; Scarfi MR 1 (2012)
Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate
in Mutation research. Genetic toxicology and environmental mutagenesis (Print)
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- Zeni O 1; Sannino A 1,2; Romeo S 1,3; Massa R 1,4; Sarti M 1; Reddy AB 5; Prihoda TJ 6; Vijayalaxmi 5; Scarfi MR 1 (literal)
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- 1. CNR Inst Electromagnet Sensing Environm, I-80124 Naples, Italy; 2. Univ Salerno, Dept Pharmaceut Sci, I-84100 Salerno, Italy; 3. Univ Naples 2, Dept Informat Engn, Aversa, Italy; 4. Univ Naples Federico II, Dept Phys, Naples, Italy; 5. Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA; 6. Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA (literal)
- Titolo
- Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate (literal)
- Abstract
- The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24 h with phytohaemagglutinin and then exposed for 20 h to an adaptive dose (AD) of a 1950 MHz RF UMTS (universal mobile telecommunication system) signal used for mobile communications, at different specific absorption rates (SAR) of 1.25, 0.6, 0.3, and 0.15 W/kg. This was followed by treatment of the cells at 48 h with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Lymphocytes were collected at the end of the 72 h total culture period. The cytokinesis-block method was used to record the frequency of micronuclei (MN) as genotoxicity end-point. When lymphocytes from six donors were pre-exposed to RF at 0.3 W/kg SAR and then treated with MMC, these cells showed a significant reduction in the frequency of MN, compared with the cells treated with MMC alone: this result is indicative of induction of AR. The results from our earlier study indicated that lymphocytes that were stimulated for 24 h, exposed for 20 h to a 900 MHz RF GSM (global system for mobile communication) signal at 1.25 W/kg SAR and then treated with 100 ng/ml MMC, also exhibited AR. These overall data suggest that the induction of AR depends on RF frequency, type of the signal and SAR. Further characterization of RF-induced AR is in progress. (literal)
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