Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ejpb.2012.11.025 (literal)

Alternative label

• Dritan Hasa, Beatrice Perissutti, Stefano Dall'Acqua, Michele R. Chierotti, Roberto Gobetto, Iztok Grabnar, Cinzia Cepek, Dario Voinovich (2013)
  Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer
  in European journal of pharmaceutics and biopharmaceutics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dritan Hasa, Beatrice Perissutti, Stefano Dall'Acqua, Michele R. Chierotti, Roberto Gobetto, Iztok Grabnar, Cinzia Cepek, Dario Voinovich (literal)

Pagina inizio

• 138 (literal)

Pagina fine

• 144 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 84 (literal)

Rivista

• European journal of pharmaceutics and biopharmaceutics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dritan Hasa 1, Beatrice Perissutti 1, Stefano Dall'Acqua 2, Michele R. Chierotti 3, Roberto Gobetto 3, Iztok Grabnar 4, Cinzia Cepek 5, Dario Voinovich1 1 Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, I- 34127 Trieste, Italy 2 Department of Pharmaceutical Sciences, University of Padova, via F. Marzolo 5, I-35131 Padova, Italy 3 Department of Chemistry, University of Torino, via P. Giuria 7, I-10125 Torino, Italy 4 Faculty of Pharmacy, University of Ljubljana, A?ker?eva cesta 7, SI-1000 Ljubljana, Slovenia 5 TASC-IOM-CNR AREA Science Park, S.S.14, Km. 163 Basovizza, I-34149 Trieste, Italy (literal)

Titolo

• Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer (literal)

Abstract

• Vincamine is a poorly soluble potent neuroprotector and cerebral vasodilator, used for the treatment of CNS disorders. In some cases the bioavailability of pure compounds is strongly influenced by the co-administration of other constituents and in some cases the so called \"phytocomplex\" may act as enhancer of absorption of selected phytochemicals. In this paper, the oral bioavailability of vincamine when administered as a standardized Vinca minor L. leaf dry extract rather than pure indole alkaloid is demonstrated to be higher. The chosen alkaloid-enriched and standardised dry extract was widely characterised by means of HPLC-MS, PXRD, DSC, XPS, 13C and 15N solid-state NMR (SSNMR) using pure vincamine as a matter of comparison. Then, the in vitro dissolution performances of the two products and their in vivo bioavailability in rats were evaluated. The sevenfold improvement in oral bioavailability of the dry extract with respect to the pure vincamine was ascribed to interactions between the indole alkaloid and the corollary of ingredients of the dry extract, giving rise to the protonation of the alkaloid vincamine thus enhancing its dissolution in physiological fluids. Present data demonstrate that alkaloid vincamine administered as a whole plant extract has a higher bioavailability compared to the pure chemical compound. (literal)

Prodotto di

• MD.P06.016.001 Proprieta' elettroniche e strutturali di sistemi a bassa dimensionalita' (MD.P06.016.003) (Modulo)

Autore CNR

• CINZIA CEPEK (Persona)

Insieme di parole chiave

• Parole chiave di "Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer" (Insieme di parole chiave)

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Autore CNR di

• CINZIA CEPEK (Persona)

Prodotto

• MD.P06.016.001 Proprieta' elettroniche e strutturali di sistemi a bassa dimensionalita' (MD.P06.016.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of pharmaceutics and biopharmaceutics (Rivista)

Insieme di parole chiave di

• Parole chiave di "Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer" (Insieme di parole chiave)