Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. (Articolo in rivista)

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  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. (Articolo in rivista) (literal)
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  • 2012-01-01T00:00:00+01:00 (literal)
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  • Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O'Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B, Herder C, Munroe PB, Caulfield M, Antti J, Mangino M, Small K, Miljkovic I, Liu Y, Atalay M, Kiess W, James AL, Rivadeneira F, Uitterlinden AG, Palmer CN, Doney AS, Willemsen G, Smit JH, Campbell S, Polasek O, Bonnycastle LL, Hercberg S, Dimitriou M, Bolton JL, Fowkes GR, Kovacs P, Lindström J, Zemunik T, Bandinelli S, Wild SH, Basart HV, Rathmann W, Grallert H; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Maerz W, Kleber ME, Boehm BO, Peters A, Pramstaller PP, Province MA, Borecki IB, Hastie ND, Rudan I, Campbell H, Watkins H, Farrall M, Stumvoll M, Ferrucci L, Waterworth DM, Bergman RN, Collins FS, Tuomilehto J, Watanabe RM, de Geus EJ, Penninx BW, Hofman A, Oostra BA, Psaty BM, Vollenweider P, Wilson JF, Wright AF, Hovingh GK, Metspalu A, Uusitupa M, Magnusson PK, Kyvik KO, Kaprio J, Price JF, Dedoussis GV, Deloukas P, Meneton P, Lind L, Boehnke M, Shuldiner AR, van Duijn CM, Morris AD, Toenjes A, Peyser PA, Beilby JP, Körner A, Kuusisto J, Laakso M, Bornstein SR, Schwarz PE, Lakka TA, Rauramaa R, Adair LS, Smith GD, Spector TD, Illig T, de Faire U, Hamsten A, Gudnason V, Kivimaki M, Hingorani A, Keinanen-Kiukaanniemi SM, Saaristo TE, Boomsma DI, Stefansson K, van der Harst P, Dupuis J, Pedersen NL, Sattar N, Harris TB, Cucca F, Ripatti S, Salomaa V, Mohlke KL, Balkau B, Froguel P, Pouta A, Jarvelin MR, Wareham NJ, Bouatia-Naji N, McCarthy MI, Franks PW, Meigs JB, Teslovich TM, Florez JC, Langenberg C, Ingelsson E, Prokopenko I, Barroso I. (2012)
    Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O'Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B, Herder C, Munroe PB, Caulfield M, Antti J, Mangino M, Small K, Miljkovic I, Liu Y, Atalay M, Kiess W, James AL, Rivadeneira F, Uitterlinden AG, Palmer CN, Doney AS, Willemsen G, Smit JH, Campbell S, Polasek O, Bonnycastle LL, Hercberg S, Dimitriou M, Bolton JL, Fowkes GR, Kovacs P, Lindström J, Zemunik T, Bandinelli S, Wild SH, Basart HV, Rathmann W, Grallert H; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Maerz W, Kleber ME, Boehm BO, Peters A, Pramstaller PP, Province MA, Borecki IB, Hastie ND, Rudan I, Campbell H, Watkins H, Farrall M, Stumvoll M, Ferrucci L, Waterworth DM, Bergman RN, Collins FS, Tuomilehto J, Watanabe RM, de Geus EJ, Penninx BW, Hofman A, Oostra BA, Psaty BM, Vollenweider P, Wilson JF, Wright AF, Hovingh GK, Metspalu A, Uusitupa M, Magnusson PK, Kyvik KO, Kaprio J, Price JF, Dedoussis GV, Deloukas P, Meneton P, Lind L, Boehnke M, Shuldiner AR, van Duijn CM, Morris AD, Toenjes A, Peyser PA, Beilby JP, Körner A, Kuusisto J, Laakso M, Bornstein SR, Schwarz PE, Lakka TA, Rauramaa R, Adair LS, Smith GD, Spector TD, Illig T, de Faire U, Hamsten A, Gudnason V, Kivimaki M, Hingorani A, Keinanen-Kiukaanniemi SM, Saaristo TE, Boomsma DI, Stefansson K, van der Harst P, Dupuis J, Pedersen NL, Sattar N, Harris TB, Cucca F, Ripatti S, Salomaa V, Mohlke KL, Balkau B, Froguel P, Pouta A, Jarvelin MR, Wareham NJ, Bouatia-Naji N, McCarthy MI, Franks PW, Meigs JB, Teslovich TM, Florez JC, Langenberg C, Ingelsson E, Prokopenko I, Barroso I. (literal)
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  • http://www.ncbi.nlm.nih.gov/pubmed/22885924 (literal)
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  • These authors contributed equally to this work. Robert A Scott, Vasiliki Lagou & Ryan P Welch Affiliations Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Robert A Scott, Jian'an Luan, Nita G Forouhi, Ruth J F Loos, Nicholas J Wareham & Claudia Langenberg Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. Vasiliki Lagou, Reedik Mägi, Anubha Mahajan, Momoko Horikoshi, Cecilia M Lindgren, Andrew P Morris, Nigel W Rayner, Neil Robertson, John F Peden, Anuj Goel, Letizia Marullo, Hugh Watkins, Martin Farrall, Mark I McCarthy & Inga Prokopenko Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Vasiliki Lagou, Momoko Horikoshi, Nigel W Rayner, Neil Robertson, Mark I McCarthy & Inga Prokopenko Bioinformatics Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan, USA. Ryan P Welch Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Ryan P Welch, Carlo Sidore, Anne U Jackson, Hyun Min Kang, Heather M Stringham, Michael Boehnke & Tanya M Teslovich Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Ryan P Welch, Carlo Sidore, Anne U Jackson, Hyun Min Kang, Heather M Stringham, Michael Boehnke & Tanya M Teslovich Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Eleanor Wheeler, Stavroula Kanoni, Kathleen Stirrups, Sarah Edkins, Panos Deloukas & Inês Barroso Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA. May E Montasser, Jeffrey R O'Connell & Alan R Shuldiner Estonian Genome Center, University of Tartu, Tartu, Estonia. Reedik Mägi, Markus Perola, Tõnu Esko & Andres Metspalu Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Rona J Strawbridge, Bengt Sennblad, Lasse Folkersen & Anders Hamsten Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Rona J Strawbridge, Lasse Folkersen & Anders Hamsten Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Emil Rehnberg, Stefan Gustafsson, Tove Fall, Patrik K E Magnusson, Nancy L Pedersen & Erik Ingelsson Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Laura J Rasmussen-Torvik Universite Lille Nord de France, Lille, France. Loïc Yengo, Cecile Lecoeur, Philippe Froguel & Nabila Bouatia-Naji Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France. Loïc Yengo, Cecile Lecoeur, Philippe Froguel & Nabila Bouatia-Naji Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Malmö, Sweden. Dmitry Shungin, Tibor V Varga & Paul W Franks Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden. Dmitry Shungin & Paul W Franks Department of Odontology, Umeå University, Umeå, Sweden. Dmitry Shungin Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. Serena Sanna, Carlo Sidore, Mulas Antonella & Francesco Cucca Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy. Carlo Sidore & Francesco Cucca Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK. Paul C D Johnson & Ian Ford Interuniversity Cardiology Institute of the Netherlands (ICIN), Durrer Center for Cardiogenetic Research, Utrecht, The Netherlands. J Wouter Jukema & Stella Trompet Departmentt of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. J Wouter Jukema & Stella Trompet Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark Caulfield The Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark Caulfield Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Niek Verweij & Pim van der Harst deCODE genetics, Rekjavik, Iceland. Gudmar Thorleifsson, Augustine Kong & Kari Stefansson Department of Biological Psychology, VU University & EMGO+ Institute, Amsterdam, The Netherlands. Jouke-Jan Hottenga, Gonneke Willemsen, Eco J C de Geus & Dorret I Boomsma University College London Genetics Institute (UGI), University College London, London, UK. Sonia Shah Icelandic Heart Association, Kopavogur, Iceland. Albert V Smith & Vilmundur Gudnason Faculty of Medicine, University of Iceland, Reykjavík, Iceland. Albert V Smith, Vilmundur Gudnason & Kari Stefansson Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Christian Gieger & Martina Müller-Nurasyid Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Perttu Salo, Markus Perola & Jula Antti Institute of Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland. Markus Perola, Jaakko Kaprio & Samuli Ripatti MRC Council Centre for Causal Analyses in Translational Epidemiology (CAiTE) Centre, School of Social and Community Medicine, University of Bristol, Bristol, UK. Nicholas J Timpson, David M Evans & George Davey Smith School of Social and Community Medicine, University of Bristol, Bristol, UK. Beate St Pourcain Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Ying Wu & Karen L Mohlke Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Jeanette S Andrews Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. Jennie Hui, Alan L James & John P Beilby School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia. Jennie Hui School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia. Jennie Hui & John P Beilby PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia. Jennie Hui & John P Beilby Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA. Lawrence F Bielak, Wei Zhao & Patricia A Peyser MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. Pau Navarro, Veronique Vitart, Caroline Hayward, Susan Campbell, Nicholas D Hastie & Alan F Wright Centre for Medical Systems Biology (CMSB), Leiden, The Netherlands. Aaron Isaacs, Fernando Rivadeneira, Andre G Uitterlinden, Ben A Oostra & Cornelia M van Duijn Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Aaron Isaacs, Sara M Willems, Ben A Oostra & Cornelia M van Duijn Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Tõnu Esko, Evelin Mihailov & Andres Metspalu Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Ross M Fraser, Jennifer L Bolton, Gerard R Fowkes, Sarah H Wild, Igor Rudan, Harry Campbell, James F Wilson & Jackie F Price The Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. Benjamin F Voight Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Benjamin F Voight Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. Soumya Raychaudhuri Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA. Soumya Raychaudhuri Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. Han Chen, Ching-Ti Liu & Josée Dupuis Boston University Data Coordinating Center, Boston, Massachusetts, USA. Denis Rybin Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Jacques S Beckmann The Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland. Jacques S Beckmann Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health (NIH), Bethesda, Maryland, USA. Peter S Chines, Lori L Bonnycastle & Francis S Collins Genetics, GlaxoSmithKline, Upper Merion, Pennsylvania, USA. Kijoung Song & Dawn M Waterworth Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA. Toshiko Tanaka & Luigi Ferrucci Illumina, Inc., Essex, UK. John F Peden Department of Cardiovascular Medicine, University of Oxford, Oxford, UK. Anuj Goel, Peter P Pramstaller, Hugh Watkins & Martin Farrall Centre for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated Institute of the University of Lübeck). Andrew A Hicks Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA. Ping An, Michael A Province & Ingrid B Borecki Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Anders Franco-Cereceda Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy. Letizia Marullo Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Hanneke Jansen Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Albertine J Oldehinkel University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Marcel Bruinenberg Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA. James S Pankow Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Kari E North Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Kari E North Section for Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden. Göran Hallmans Pirkanmaa Hospital District, Tampere, Finland. Heikki Oksa & Timo E Saaristo Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, Maryland, USA. Ramaiah Nagaraja Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Stephan J L Bakker Department of Epidemiology and Public Health, University College London, London, UK. Meena Kumari, Mika Kivimaki, Aroon Hingorani & Claudia Langenberg Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Bruna Gigante & Ulf de Faire Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Christian Herder Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Massimo Mangino, Kerrin Small & Tim D Spector Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Iva Miljkovic Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Yongmei Liu Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Mustafa Atalay & Timo A Lakka Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Wieland Kiess, Michael Stumvoll, Anke Toenjes & Antje Körner Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany. Wieland Kiess & Antje Körner School of Medicine and Pharmacology, The University of Western Australia, Nedlands, Western Australia, Australia. Alan L James Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. Alan L James Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira & Andre G Uitterlinden Netherlands Consortium for Healthy Ageing (NCHAH) of the Genomics Initiative (NGI), Leiden, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden, Ben A Oostra & Cornelia M van Duijn Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden, Albert Hofman & Cornelia M van Duijn Medical Research Institute, University of Dundee, Dundee, UK. Colin N A Palmer, Alex S F Doney & Andrew D Morris Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands. Johannes H Smit & Brenda W Penninx Faculty of Medicine, University of Split, Split, Croatia. Ozren Polasek & Tatijana Zemunik U557 Institut National de la Santé et de la Recherche Médicale (INSERM), U1125 Institut National de la Recherche Agronomique (INRA), Université Paris 13, Bobigny, France. Serge Hercberg Department of Dietetics and Nutrition, Harokopio University, Athens, Greece. Maria Dimitriou & George V Dedoussis University of Leipzig, Interdisciplinary Center for Clinical Research, Leipzig, Germany. Peter Kovacs Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaana Lindström & Jaakko Tuomilehto Geriatric Department, Azienda Sanitaria Firenze, Florence, Italy. Stefania Bandinelli Department Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Hanneke V Basart & G Kees Hovingh Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Wolfgang Rathmann Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Harald Grallert & Thomas Illig Synlab Academy, Mannheim, Germany. Winfried Maerz Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. Winfried Maerz & Marcus E Kleber Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany. Marcus E Kleber Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany. Bernhard O Boehm Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Annette Peters Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller & Anke Toenjes Department of Medicine, University of Leipzig, Leipzig, Germany. Michael Stumvoll Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Richard N Bergman South Ostrobothnia Central Hospital, Seinäjoki, Finland. Jaakko Tuomilehto Red RECAVA (La Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares) Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain. Jaakko Tuomilehto Centre for Vascular Prevention, Danube-University Krems, Krems, Austria. Jaakko Tuomilehto Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. Richard M Watanabe Department of Physiology & Biophysics, Keck School of Medicine of the University of Souterhn California, Los Angeles, California, USA. Richard M Watanabe Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. Bruce M Psaty Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA. Bruce M Psaty Department of Epidemiology, University of Washington, Seattle, Washington, USA. Bruce M Psaty Department of Health Services, University of Washington, Seattle, Washington, USA. Bruce M Psaty Department of Internal Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland. Peter Vollenweider Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Matti Uusitupa Research Unit, Kuopio University Hospital, Kuopio, Finland. Matti Uusitupa Odense Patient data Explorative Network (OPEN), Odense, Denmark. Kirsten O Kyvik Institute of Regional Health Services Research, Odense, Denmark. Kirsten O Kyvik Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. Jaakko Kaprio Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. Jaakko Kaprio U872 INSTERM, Centre de Recherche des Cordeliers, Paris, France. Pierre Meneton Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Lars Lind Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA. Alan R Shuldiner Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Johanna Kuusisto & Markku Laakso Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany. Stefan R Bornstein & Peter E H Schwarz Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Timo A Lakka & Rainer Rauramaa Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Rainer Rauramaa Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Linda S Adair Hannover Unified Biobank, Hannover Medical School, Hannover, Germany. Thomas Illig Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. Anders Hamsten Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland. Sirkka M Keinanen-Kiukaanniemi Unit of General Practice, Oulu University Hospital, Oulu, Finland. Sirkka M Keinanen-Kiukaanniemi Finnish Diabetes Association, Tampere, Finland. Timo E Saaristo National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. Josée Dupuis British Heart Foundation (BHF) Building, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Naveed Sattar Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, NIH, Bethesda, Maryland, USA. Tamara B Harris Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland. Samuli Ripatti Wellcome Trust Sanger Institute, Hinxton, UK. Samuli Ripatti Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland. Veikko Salomaa INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP) Center for Research in Epidemiology and Public Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif, France. Beverley Balkau University Paris Sud 11, UMRS 1018, Villejuif, France. Beverley Balkau Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK. Philippe Froguel Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland. Anneli Pouta Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Jarvelin Biocenter Oulu, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin Department of Epidemiology and Biostatistics, School of Public Health, MRC-Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK. Marjo-Riitta Jarvelin Institute of Health Sciences, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin INSERM U970, Paris Cardiovascular Research Center (PARCC), Paris, France. Nabila Bouatia-Naji Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK. Mark I McCarthy Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Paul W Franks General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA. James B Meigs Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. James B Meigs & Jose C Florez Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. Jose C Florez Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Jose C Florez Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Jose C Florez NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso These authors jointly directed this work. Jose C Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko & Inês Barroso Consortia DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (literal)
Titolo
  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. (literal)
Abstract
  • Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control (literal)
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