Distinct beta-cell defects in impaired fasting glucose and impaired glucose tolerance (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Distinct beta-cell defects in impaired fasting glucose and impaired glucose tolerance (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2337/db11-0995 (literal)

Alternative label

• Kanat, M.;Mari, A.;Norton, L.;Winnier, D.;DeFronzo, R.A.;Jenkinson, C.;Abdul-Ghani, M.A. (2012)
  Distinct beta-cell defects in impaired fasting glucose and impaired glucose tolerance
  in Diabetes (N.Y.N.Y.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Kanat, M.;Mari, A.;Norton, L.;Winnier, D.;DeFronzo, R.A.;Jenkinson, C.;Abdul-Ghani, M.A. (literal)

Pagina inizio

• 447 (literal)

Pagina fine

• 453 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/22275086 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 61 (literal)

Rivista

• Diabetes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States (literal)

Titolo

• Distinct beta-cell defects in impaired fasting glucose and impaired glucose tolerance (literal)

Abstract

• To characterize the defects in b-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, b-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model by Mari in 172 Mexican Americans. A subgroup (n = 70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and secondphase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in b-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased b-cell rate sensitivity. In IFG subjects, the defect in b-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (?C-pep [AUC]0-12) was inversely related with the increase in FPG concentration (r = 236, r = 0.001), whereas ?C-pep[AUC]15-120 positively correlated with FPG concentration (r = 0.29, r , 0.05). When adjusted for the prevailing level of insulin resistance, firstphase insulin secretion was markedly decreased in both IFG and IGT, whereas second-phase insulin secretion was decreased only in IGT. These results demonstrate distinct defects in b-cell function in IFG and IGT (literal)

Prodotto di

• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes (Rivista)