http://www.cnr.it/ontology/cnr/individuo/prodotto/ID193811
Synthesis and characterization of the 47-residue heterodimeric antimicrobial peptide distinctin, featuring directed disulfide bridge formation. (Articolo in rivista)
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- Synthesis and characterization of the 47-residue heterodimeric antimicrobial peptide distinctin, featuring directed disulfide bridge formation. (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/bip.22087 (literal)
- Alternative label
Mullen DG, Verardi R, Porcelli F, Scaloni A, Barany G, Veglia G. (2012)
Synthesis and characterization of the 47-residue heterodimeric antimicrobial peptide distinctin, featuring directed disulfide bridge formation.
in Biopolymers (Print); Wiley, New York (Stati Uniti d'America)
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- Mullen DG, Verardi R, Porcelli F, Scaloni A, Barany G, Veglia G. (literal)
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- http://onlinelibrary.wiley.com/doi/10.1002/bip.22087/abstract;jsessionid=AE4BE8BBBF73B1003FF3EACD689211D2.d02t04 (literal)
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- Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455
Department of Chemistry, University of Minnesota, Minneapolis, MN 55455
Department for Innovation in Biological, Agro-Food and Forest Systems, DIBAF, University of Tuscia, Viterbo, Italy
Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Naples, Italy (literal)
- Titolo
- Synthesis and characterization of the 47-residue heterodimeric antimicrobial peptide distinctin, featuring directed disulfide bridge formation. (literal)
- Abstract
- Distinctin, a 47-residue heterodimeric peptide with potent antimicrobial activity, comprises two monomeric units linked covalently by a disulfide bond between Cys19 from the 22-residue A chain and Cys23 from the 25-residue B chain. Previous synthetic strategies involved assemblies of the two individual chains, followed by their co-oxidation to form the connecting disulfide bridge, and resulted in a mixture of three species: two homodimers and one heterodimer. Here, we report synthesis of exclusively heterodimeric distinctin, using recently developed tactics for directed disulfide bridge formation. Material prepared this way was characterized and found to be suitable for more detailed structural studies. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 479-484, 2012. (literal)
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