Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. (Articolo in rivista)

Type
Label
  • Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • IL6R Genetics Consortium Emerging Risk Factors Collaboration, Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AA, Trip MD, Steri M, Witteman JC, Qi L, van der Schoot CE, de Faire U, Erdmann J, Stringham HM, Koenig W, Rader DJ, Melzer D, Reich D, Psaty BM, Kleber ME, Panagiotakos DB, Willeit J, Wennberg P, Woodward M, Adamovic S, Rimm EB, Meade TW, Gillum RF, Shaffer JA, Hofman A, Onat A, Sundström J, Wassertheil-Smoller S, Mellström D, Gallacher J, Cushman M, Tracy RP, Kauhanen J, Karlsson M, Salonen JT, Wilhelmsen L, Amouyel P, Cantin B, Best LG, Ben-Shlomo Y, Manson JE, Davey-Smith G, de Bakker PI, O'Donnell CJ, Wilson JF, Wilson AG, Assimes TL, Jansson JO, Ohlsson C, Tivesten Å, Ljunggren Ö, Reilly MP, Hamsten A, Ingelsson E, Cambien F, Hung J, Thomas GN, Boehnke M, Schunkert H, Asselbergs FW, Kastelein JJ, Gudnason V, Salomaa V, Harris TB, Kooner JS, Allin KH, Nordestgaard BG, Hopewell JC, Goodall AH, Ridker PM, Hólm H, Watkins H, Ouwehand WH, Samani NJ, Kaptoge S, Di Angelantonio E, Harari O, Danesh J., Assimes TL, Quertermous T, Go AS, Hlatky MA, Knowles JW, Gudnason V, Smith AV, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C, Nelson CP, Braund PS, Samani NJ, Hall AS, Balmforth AJ, Thompson JR, Rendon A, Wilde AA, Trip MD, van der Schoot CE, Kastelein JJ, Ouwehand WH, Sivapalaratnam S, Maiwald S, Basart H, Motazacker M, de Jong JS, Dekker LR, Tanck M, Bezzina CR, Whincup PH, Morris RW, Wannamethee SG, Willeit J, Kiechl S, Gallacher J, Yarnell JW, Lowe G, Rumley A, Samani NJ, Goodall AH, Cambien F, Cushman M, Mukamal KJ, Nordestgaard BG, Tybjærg-Hansen A, Allin KH, Salomaa V, Havulinna AS, Lokki ML, Nieminen MS, Ripatti S, Sinisalo J, Hung J, McQuillan BM, Beilby JP, Thompson PL, Hólm H, Thorleifsson G, Thorgeirsson G, Thorsteinsdóttir U, Stefansson K, Salomaa V, Jula A, Männistö S, Perola M, Tikkanen E, Asselbergs FW, Boer JM, Onland-Moret NC, van der Schouw YT, Verschuren WM, de Bakker PI, Wennberg P, Jansson JH, Salomaa V, Woodward M, Benjamin EJ, Dupuis J, Fontes JD, Yin X, O'Donnell CJ, Boehnke M, Stringham HM, Tuomilehto J, Schunkert H, Erdmann J, Koenig IR, Nahrstaedt J, Loley C, Stark K, Willenborg C, Hengstenberg C, Schreiber S, Preuss M, Franks PW, Barroso I, Hallmans G, Shungin D, Thomas GN, Cheng KK, Lam TH, Jiang CC, Reich D, Harris TB, Rimm EB, Pai J, Hopewell JC, Collins R, Parish S, Armitage J, Stringham HM, Jackson A, Hveem K, Psaty BM, Wiggins KL, Heckbert SR, Smith NL, Bis JC, Melzer D, Ferrucci L, Guralnik JM, Bandinelli S, Singleton AB, Kauhanen J, Salonen JT, Tuomainen TP, Kurl S, Meade TW, Chambers JC, Kooner JS, Zhang W, Kooner AS, Das D, Kleber ME, März W, Scharnagl H, Böhm BO, Winkelmann BR, Cushman M, Tracy RP, Folsom AR, Psaty BM, Shea SJ, Stringham HM, Laakso M, Kuusisto J, Koenig W, Baumert J, Thorand B, Illig T, Meisinger C, Wilhelmsen L, Rosengren A, Jansson JO, Adamovic S, Karlsson MK, Ljunggren Ö, Mellström D, Ohlsson C, Tivesten Å, Gillum RF, Rimm EB, Manson JE, Qi L, Hu FB, Hankinson SE, Shaffer JA, Davidson KW, Wilson JF, Fraser R, Wild S, Campbell H, Rader DJ, Reilly MP, Qasim A, Qu L, Li M, Ingelsson E, Lind L, Sundström J, Syvänen AC, Amouyel P, Arveiler D, Clarke R, Watkins H, Farrall M, Hopewell JC, Peden JF, Saleheen D, Deloukas P, Sheikh N, Rasheed A, Danesh J, Cantin B, Dagenais GR, Witteman JC, Hofman A, Dehghan A, van Duijn CM, Uitterlinden AG, Steri M, Abecasis GR, Cucca F, Sanna S, Uda M, Schlessinger D, Hamsten A, Sabater-Lleal M, Silveira A, de Faire U, Gigante B, Best LG, Howard BV, Davey-Smith G, Ben-Shlomo Y, Onat A, Ingelsson E, Sundström J, Lind L, Basu S, Syvänen AC, Ridker PM, Chasman DI, Rose LM, Wassertheil-Smoller S, Ridker PM, Buring J. (2012)
    Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
    in Lancet (Br. ed., Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • IL6R Genetics Consortium Emerging Risk Factors Collaboration, Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AA, Trip MD, Steri M, Witteman JC, Qi L, van der Schoot CE, de Faire U, Erdmann J, Stringham HM, Koenig W, Rader DJ, Melzer D, Reich D, Psaty BM, Kleber ME, Panagiotakos DB, Willeit J, Wennberg P, Woodward M, Adamovic S, Rimm EB, Meade TW, Gillum RF, Shaffer JA, Hofman A, Onat A, Sundström J, Wassertheil-Smoller S, Mellström D, Gallacher J, Cushman M, Tracy RP, Kauhanen J, Karlsson M, Salonen JT, Wilhelmsen L, Amouyel P, Cantin B, Best LG, Ben-Shlomo Y, Manson JE, Davey-Smith G, de Bakker PI, O'Donnell CJ, Wilson JF, Wilson AG, Assimes TL, Jansson JO, Ohlsson C, Tivesten Å, Ljunggren Ö, Reilly MP, Hamsten A, Ingelsson E, Cambien F, Hung J, Thomas GN, Boehnke M, Schunkert H, Asselbergs FW, Kastelein JJ, Gudnason V, Salomaa V, Harris TB, Kooner JS, Allin KH, Nordestgaard BG, Hopewell JC, Goodall AH, Ridker PM, Hólm H, Watkins H, Ouwehand WH, Samani NJ, Kaptoge S, Di Angelantonio E, Harari O, Danesh J., Assimes TL, Quertermous T, Go AS, Hlatky MA, Knowles JW, Gudnason V, Smith AV, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C, Nelson CP, Braund PS, Samani NJ, Hall AS, Balmforth AJ, Thompson JR, Rendon A, Wilde AA, Trip MD, van der Schoot CE, Kastelein JJ, Ouwehand WH, Sivapalaratnam S, Maiwald S, Basart H, Motazacker M, de Jong JS, Dekker LR, Tanck M, Bezzina CR, Whincup PH, Morris RW, Wannamethee SG, Willeit J, Kiechl S, Gallacher J, Yarnell JW, Lowe G, Rumley A, Samani NJ, Goodall AH, Cambien F, Cushman M, Mukamal KJ, Nordestgaard BG, Tybjærg-Hansen A, Allin KH, Salomaa V, Havulinna AS, Lokki ML, Nieminen MS, Ripatti S, Sinisalo J, Hung J, McQuillan BM, Beilby JP, Thompson PL, Hólm H, Thorleifsson G, Thorgeirsson G, Thorsteinsdóttir U, Stefansson K, Salomaa V, Jula A, Männistö S, Perola M, Tikkanen E, Asselbergs FW, Boer JM, Onland-Moret NC, van der Schouw YT, Verschuren WM, de Bakker PI, Wennberg P, Jansson JH, Salomaa V, Woodward M, Benjamin EJ, Dupuis J, Fontes JD, Yin X, O'Donnell CJ, Boehnke M, Stringham HM, Tuomilehto J, Schunkert H, Erdmann J, Koenig IR, Nahrstaedt J, Loley C, Stark K, Willenborg C, Hengstenberg C, Schreiber S, Preuss M, Franks PW, Barroso I, Hallmans G, Shungin D, Thomas GN, Cheng KK, Lam TH, Jiang CC, Reich D, Harris TB, Rimm EB, Pai J, Hopewell JC, Collins R, Parish S, Armitage J, Stringham HM, Jackson A, Hveem K, Psaty BM, Wiggins KL, Heckbert SR, Smith NL, Bis JC, Melzer D, Ferrucci L, Guralnik JM, Bandinelli S, Singleton AB, Kauhanen J, Salonen JT, Tuomainen TP, Kurl S, Meade TW, Chambers JC, Kooner JS, Zhang W, Kooner AS, Das D, Kleber ME, März W, Scharnagl H, Böhm BO, Winkelmann BR, Cushman M, Tracy RP, Folsom AR, Psaty BM, Shea SJ, Stringham HM, Laakso M, Kuusisto J, Koenig W, Baumert J, Thorand B, Illig T, Meisinger C, Wilhelmsen L, Rosengren A, Jansson JO, Adamovic S, Karlsson MK, Ljunggren Ö, Mellström D, Ohlsson C, Tivesten Å, Gillum RF, Rimm EB, Manson JE, Qi L, Hu FB, Hankinson SE, Shaffer JA, Davidson KW, Wilson JF, Fraser R, Wild S, Campbell H, Rader DJ, Reilly MP, Qasim A, Qu L, Li M, Ingelsson E, Lind L, Sundström J, Syvänen AC, Amouyel P, Arveiler D, Clarke R, Watkins H, Farrall M, Hopewell JC, Peden JF, Saleheen D, Deloukas P, Sheikh N, Rasheed A, Danesh J, Cantin B, Dagenais GR, Witteman JC, Hofman A, Dehghan A, van Duijn CM, Uitterlinden AG, Steri M, Abecasis GR, Cucca F, Sanna S, Uda M, Schlessinger D, Hamsten A, Sabater-Lleal M, Silveira A, de Faire U, Gigante B, Best LG, Howard BV, Davey-Smith G, Ben-Shlomo Y, Onat A, Ingelsson E, Sundström J, Lind L, Basu S, Syvänen AC, Ridker PM, Chasman DI, Rose LM, Wassertheil-Smoller S, Ridker PM, Buring J. (literal)
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  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316 (literal)
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  • ADVANCE: Themistocles L Assimes, Thomas Quertermous, Alan S Go, Mark A Hlatky, Joshua W Knowles; AGES: Vilmundur Gudnason, Albert V Smith; ATTICA: Demosthenes B Panagiotakos, Christina Chrysohoou, Christos Pitsavos, Christodoulos Stefanadis; BHF-FHS: Christopher P Nelson, Peter S Braund, Nilesh J Samani, Alistair S Hall, Anthony J Balmforth, John R Thompson; BLOODOMICS: Augusto Rendon, Arthur A M Wilde, Mieke D Trip, C Ellen van der Schoot, John J P Kastelein, Willem H Ouwehand, Suthesh Sivapalaratnam, Stephani Maiwald, Hanneke Basart, Mahdi Motazacker, Jonas S S G de Jong, Lucas R C Dekker, Michael Tanck, Connie R Bezzina; BRHS: Peter H Whincup, Richard W Morris, S Goya Wannamethee; BRUN: Johann Willeit, Stefan Kiechl; CAPS: John Gallacher, John W G Yarnell, Gordon Lowe, Ann Rumley; CARDIOGENICS: Nilesh J Samani, Alison H Goodall, Francois Cambien (see appendix p 26 for acknowledgments); CHS: Mary Cushman, Kenneth J Mukamal (see http://www.chs-nhlbi.org for acknowledgments); COPEN/CIHDS: Børge G Nordestgaard, Anne Tybjærg-Hansen, Kristine H Allin; COROGENE: Veikko Salomaa, Aki S Havulinna, Marja-Liisa Lokki, Markku S Nieminen, Samuli Ripatti, Juha Sinisalo; CUDAS/CUPID: Joseph Hung, Brendan M McQuillan, John P Beilby, Peter L Thompson; DECODE: Hilma Hólm, Gumar Thorleifsson, Gumundur Thorgeirsson, Unnur Thorsteinsdóttir, Kari Stefansson; DILGOM: Veikko Salomaa, Antti Jula, Satu Männistö, Markus Perola, Emmi Tikkanen; EPICNL: Folkert W Asselbergs, Jolanda M A Boer, N Charlotte Onland-Moret, Yvonne T van der Schouw, W M Monique Verschuren, Paul I W de Bakker; FIA: Patrik Wennberg, Jan-Håkan Jansson; FINRISK92,97: Veikko Salomaa; FLETCHER: Mark Woodward; FRAM: Emelia J Benjamin, Josée Dupuis, João D Fontes, Xiaoyan Yin, Christopher J O'Donnell; FUSION: Michael Boehnke, Heather M Stringham, Jaakko Tuomilehto; GerMIFS1 / GerMIFS2: Heribert Schunkert, Jeanette Erdmann, Inke R Koenig, Janja Nahrstaedt, Christina Loley, Klaus Stark, Christina Willenborg, Christian Hengstenberg, Stefan Schreiber, Michael Preuss; GLACIER: Paul W Franks, Inês Barroso, Göran Hallmans, Dmitry Shungin; Guangzhou Biobank Cohort Study: G Neil Thomas, Kar Keung Cheng, Tai Hing Lam, Chao Chiang Jiang; HEALTH: David Reich, Tamara B Harris; HPFS: Eric B Rimm, Jennifer Pai; HPS: Jemma C Hopewell, Rory Collins, Sarah Parish, Jane Armitage; HUNT: Heather M Stringham, Anne Jackson, Kristian Hveem; HVHS: Bruce M Psaty, Kerri L Wiggins, Susan R Heckbert, Nicholas L Smith, Joshua C Bis; inCHIANTI: David Melzer, Luigi Ferrucci, Jack M Guralnik, Stefania Bandinelli, Andrew B Singleton; KIHD: Jussi Kauhanen, Jukka T Salonen, Tomi-Pekka Tuomainen, Sudhir Kurl; LEADER: Tom W Meade; LOLIPOP: John C Chambers, Jaspal S Kooner, Weihua Zhang, Angad S Kooner, Debashis Das; LURIC: Marcus E Kleber, Winfried März, Hubert Scharnagl, Bernhard O Böhm, Bernhard R Winkelmann; MESA: Mary Cushman, Russell P Tracy, Aaron R Folsom, Bruce M Psaty, Steven J Shea (see http://www.mesa-nhlbi.org for acknowledgments); METSIM: Heather M Stringham, Markku Laakso, Johanna Kuusisto; MOGERAUG: Wolfgang Koenig, Jens Baumert, Barbara Thorand, Thomas Illig, Christa Meisinger; MOSWEGOT: Lars Wilhelmsen, Annika Rosengren; MrOS: John-Olov Jansson, Svetlana Adamovic, Magnus K Karlsson, Östen Ljunggren, Dan Mellström, Claes Ohlsson, Åsa Tivesten; NHANESIII: Richard F Gillum; NHS: Eric B Rimm, JoAnn E Manson, Lu Qi, Frank B Hu, Susan E Hankinson; NSHS: Jonathan A Shaffer, Karina W Davidson; ORCADES: James F Wilson, Ross Fraser, Sarah Wild, Harry Campbell; PENNCATH: Daniel J Rader, Muredach P Reilly, Atif Qasim, Liming Qu, Mingyao Li; PIVUS: Erik Ingelsson, Lars Lind, Johan Sundström, Ann-Christine Syvänen; PRIME: Philippe Amouyel, Dominique Arveiler; PROCARDIS: Robert Clarke, Hugh Watkins, Martin Farrall, Jemma C Hopewell, John F Peden; PROMIS: Danish Saleheen, Panos Deloukas, Nasir Sheikh, Asif Rasheed, John Danesh; QUEBEC: Bernard Cantin, Gilles R Dagenais; ROTT: Jacqueline C M Witteman, Albert Hofman, Abbas Dehghan, Cornelia M van Duijn, Andre G Uitterlinden; SARDINIA: Maristella Steri, Goncalo R Abecasis, Francesco Cucca, Serena Sanna, Manuela Uda, David Schlessinger; SCARF: Anders Hamsten, Maria Sabater-Lleal, Angela Silveira; SHEEP: Ulf de Faire, Bruna Gigante; SHS: Lyle G Best, Barbara V Howard; SPEED: George Davey-Smith, Yoav Ben-Shlomo; TARFS: Altan Onat; ULSAM: Erik Ingelsson, Johan Sundström, Lars Lind, Samar Basu, Ann-Christine Syvänen; WGHS: Paul M Ridker, Daniel I Chasman, Lynda M Rose; WHI-HaBPS: Sylvia Wassertheil-Smoller; WHS: Paul M Ridker, Julie Buring. (literal)
Titolo
  • Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. (literal)
Abstract
  • Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >=0·04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34·3% (95% CI 30·4-38·2) and of interleukin 6 by 14·6% (10·7-18·4), and mean concentration of C-reactive protein was reduced by 7·5% (5·9-9·1) and of fibrinogen by 1·0% (0·7-1·3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3·4% (1·8-5·0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease. (literal)
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