Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (Articolo in rivista)

Type
Label
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV, van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ, Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis MC, Corre T, Coviello AD, d'Adamo P, Davies G, de Faire U, de Geus EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G, Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK, Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret NC, Palotie A, Paré G, Parker AN, Pedersen NL, Peeters PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Räikkönen K, Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM, Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S, van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF, Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens MC, Zygmunt M, Study TL, Arnold AM, Boomsma DI, Buring JE, Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL. (2012)
    Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV, van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ, Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis MC, Corre T, Coviello AD, d'Adamo P, Davies G, de Faire U, de Geus EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G, Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK, Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret NC, Palotie A, Paré G, Parker AN, Pedersen NL, Peeters PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Räikkönen K, Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM, Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S, van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF, Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens MC, Zygmunt M, Study TL, Arnold AM, Boomsma DI, Buring JE, Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288642/ (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands 2Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands 3Peninsula Medical School, University of Exeter, UK 4Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK 5Division of Preventive Medicine, Brigham and Women's Hospital, Boston USA 6Harvard Medical School, Boston, USA 7Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana, USA 8Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA 9Department of Twin Research and Genetic Epidemiology, King's College London, London, UK 10deCODE Genetics, Reykjavik, Iceland 11Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA 12Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands 13Queensland Institute of Medical Research, Brisbane, Australia 14Interfakultäres Institut für Genomforschung, Universität Greifswald, Germany 15Estonian Genome Center, University of Tartu, Tartu, Estonia 16Estonian Biocenter, Tartu, Estonia 17Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia 18Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 19Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands 20Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 21Broad Institute of Harvard and MIT, USA 22Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA 23Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy 24Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK 25Icelandic Heart Association, Kopavogur, Iceland 26Faculty of Medicine, University of Iceland, Reykjavik, Iceland 27Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada 28Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA 29Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany 30Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands 31Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy 32Croation Science Foundation, Zagreb, Croatia 33Department of Medical Genetics, University of Lausanne, Switzerland 34Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland 35Faculty of Medicine, University of Split, Split, Croatia 36Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands 37Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK 38Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 39Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA 40Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy 41Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA 42NHLBI Framingham Heart Study, Framingham, MA, USA 43Institute for Maternal and Child Health, IRCCS \"Burlo Garofolo\" Trieste, Italy 44University of Trieste, Trieste, Italy 45Department of Psychology, The University of Edinburgh, Edinburgh, UK 46Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 47EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands 48Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK 49Department of Nutrition and Dietetics, Harokopio University, Athens, Greece 50Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine, UK 51National Institute for Health and Welfare, Finland 52Department of General Practice and Primary Health Care, University of Helsinki, Finland 53Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland 54Folkhalsan Research Centre, Helsinki, Finland 55Vasa Central Hospital, Vasa, Finland 56Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA 57Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA 58Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA 59Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands 60Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 61Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA 62MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK 63Washington University St.Louis, St. Louis, MO, USA 64Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA 65Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA 66Diagnostic GP laboratory Eindhoven, Eindhoven, the Netherlands 67Swiss Institute of Bioinformatics, Switzerland 68Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland 69Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia 70Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands 71MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, UK 72Human genetic, Genome Institute of Singapore, Singapore 73Institute for Migration and Ethnic Studies, Zagreb, Croatia 74Department of Biostatistics, University of Washington, Seattle, WA, USA 75Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA 76Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 77Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland 78Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland 79Genetic and Molecular Epidemiology Laboratory, McMaster University, Hamilton, ON Canada 80Amgen, Cambridge, MA USA 81Foundation Medicine, Inc., Cambridge MA USA 82Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK 83Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ, USA 84Department of Clinical Health Psychology, University of Tilburg, Tilburg, the Netherlands 85Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA USA 86Group Health Research Institute, Group Health Cooperative, Seattle, WA USA 87Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA 88Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia 89Lab Cardiovascular Sciences - NIA - NIH, Baltimore, USA 90Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USA 91LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands 92Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK 93Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy, France 94Department of Epidemiology, Emory University, Atlanta, GA, USA 95The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK 96Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany 97Institute of Molecular Genetics-CNR, Pavia, Italy 98Icelandic Cancer Registry, Reykjavik, Iceland 99Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 100Municipal Health Service Brabant-Zuidoost, Helmond, the Netherlands 101Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia 102Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland 103Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald 104Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany 105Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany 106Klinikum Grosshadern, Munich, Germany 107POZOB Veldhoven, Veldhoven, the Netherlands 108Department of Endocrinology, University Medical Center Groningen, University of Groningen, the Netherlands 109Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia 110Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald, Germany 111Harvard School of Public Health, Boston, MA USA 112Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands 113Division of Cardiology, Brigham and Women's Hospital, Boston, MA USA 114National Institute on Aging, Intramural Research Program, Baltimore, MD, USA 115Institut für Community Medicine, Universität Greifswald, Germany (literal)
Titolo
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (literal)
Abstract
  • To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (P < 5 × 10-8). The new loci included genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG, PRIM1) and immune function (IL11, NLRP11, BAT2). Gene-set enrichment pathway analyses using the full GWAS dataset identified exodeoxyribonuclease, NF?B signalling and mitochondrial dysfunction as biological processes related to timing of menopause. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it