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Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. (Articolo in rivista)

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Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. (Articolo in rivista) (literal)

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Alessandro Aiuti, Manuela Tavian, Arcadi Cipponi, Francesca Ficara, Elisabetta Zappone, James Hoxie, Bruno Peault, Claudio Bordignon (1999)
Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors.
in European Journal of Immunology
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Alessandro Aiuti, Manuela Tavian, Arcadi Cipponi, Francesca Ficara, Elisabetta Zappone, James Hoxie, Bruno Peault, Claudio Bordignon (literal)

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http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291521-4141%28199906%2929:06%3C1823::AID-IMMU1823%3E3.0.CO;2-B/abstract;jsessionid=D4D87995C62EB145DE48B52A3751C706.d03t04 (literal)

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1 Telethon Institute for Gene Therapy (TIGET) Scientific Institute H. S. Raffaele, Milano, Italy 2 Institut d'Embryologie Cellulaire et Moleculaire, CNRS, Nogent-Sur-Marne, France 3 Bone Marrow Transplantation Unit, Scientific Institute H. S. Raffaele, Milano, Italy 4 University of Pennsylvania Medical Center, Philadelphia, USA (literal)

Titolo

Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. (literal)

Abstract

Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine produced by stromal cells that acts as a chemoattractant for human CD34+ progenitor cells. We investigated the expression of CXCR4, the receptor for SDF-1, on CD34+ cells from different hematopoietic sites and developmental stages. CXCR4 was detected by flow cytometry on 37 % of fetal bone marrow (BM) [gestation weeks (gw) 14 - 23] and 40 % of adult BM CD34+ cells. Interestingly, in fetal liver CD34+ cells, CXCR4 was expressed at lower levels at later stages (9 %, gw 20 - 23) compared to early stages of development (39 %, gw 7.5 - 18), suggesting a development-related change in the migratory capacity of progenitors. CXCR4 was detected at similar levels on both phenotypically primitive and committed progenitors from fetal and adult sites. However, B cell lineage progenitor and precursor cells expressed CXCR4 at the highest density (80 % of BM CD34+/CD10+ pro-B cells are CXCR4+). CXCR4 was also expressed in the fetal thymus in early T cell precursors and found to be down-regulated during T cell maturation. Finally, we found that stem cell factor, alone or in combination with other cytokines, can up-modulate CXCR4 expression on CD34+ cells by three- to fourfold. In conclusion, our results suggest that CXCR4 may play an important role in the local and systemic trafficking of human CD34+ cells as well as in human B lymphopoiesis and that its expression can be modulated by cytokines. (literal)

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