Contribution of serine racemase/d-serine pathway to neuronal apoptosis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Contribution of serine racemase/d-serine pathway to neuronal apoptosis (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1474-9726.2012.00822.x (literal)

Alternative label

• Esposito Simona1; Pristerà Andrea1; Maresca Giovanna1; Cavallaro Sebastiano2; Felsani Armando1;o Florenzano Fulvio3; Manni Luigi4; Ciotti Maria T.1; Pollegioni Loredano5; Borsello Tiziana6; Canu Nadia1,7 (2012)
  Contribution of serine racemase/d-serine pathway to neuronal apoptosis
  in Aging cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Esposito Simona1; Pristerà Andrea1; Maresca Giovanna1; Cavallaro Sebastiano2; Felsani Armando1;o Florenzano Fulvio3; Manni Luigi4; Ciotti Maria T.1; Pollegioni Loredano5; Borsello Tiziana6; Canu Nadia1,7 (literal)

Pagina inizio

• 588 (literal)

Pagina fine

• 598 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2012 Jun 5. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Aging cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Istituto di Biologia Cellulare e Neurobiologia, CNR, Roma, Italy. 2 Istituto di Scienze Neurologiche, Centro di Genomica Funzionale, CNR, Catania, Italy. 3 Fondazione Santa Lucia and European Brain Research Institute, Roma, Italy. 4 Istituto di Farmacologia Traslazionale, CNR, Roma, Italy. 5 Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy. 6 Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. 7 Dipartmento di Neuroscienze, Università di Tor Vergata, Roma, Italy (literal)

Titolo

• Contribution of serine racemase/d-serine pathway to neuronal apoptosis (literal)

Abstract

• Recent data indicate that age-related N-methyl-d-aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d-serine content. As apoptosis is associated with several diseases and conditions that generally occur with age, we investigated the modulation of SR/d-serine pathway during neuronal apoptosis and its impact on survival. We found that in cerebellar granule neurons (CGNs), undergoing apoptosis SR/d-serine pathway is crucially regulated. In the early phase of apoptosis, the expression of SR is reduced, both at the protein and RNA level through pathways, upstream of caspase activation, involving ubiquitin proteasome system (UPS) and c-Jun N-terminal kinases (JNKs). Forced expression of SR, together with treatment with NMDA and d-serine, blocks neuronal death, whereas pharmacological inhibition and Sh-RNA-mediated suppression of endogenous SR exacerbate neuronal death. In the late phase of apoptosis, the increased expression of SR contribute to the last, NMDAR-mediated, wave of cell death. These findings are relevant to our understanding of neuronal apoptosis and NMDAR activity regulation, raising further questions as to the role of SR/d-serine in those neuro-pathophysiological processes, such as aging and neurodegenerative diseases characterized by a convergence of apoptotic mechanisms and NMDAR dysfunction. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Autore CNR

• nadia canu (Persona)
• ARMANDO FELSANI (Unità di personale interno)
• MARIA TERESA CIOTTI (Persona)
• LUIGI MANNI (Unità di personale interno)

Incoming links:

Autore CNR di

• LUIGI MANNI (Unità di personale interno)
• ARMANDO FELSANI (Unità di personale interno)
• MARIA TERESA CIOTTI (Persona)
• nadia canu (Persona)

Prodotto

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Aging cell (Rivista)