Nerve growth factor: from the early discoveries to the potential clinical use (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Nerve growth factor: from the early discoveries to the potential clinical use (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/1479-5876-10-239 (literal)

Alternative label

• Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi and Luigi Manni (2012)
  Nerve growth factor: from the early discoveries to the potential clinical use
  in Journal of translational medicine (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi and Luigi Manni (literal)

Pagina inizio

• 239-1 (literal)

Pagina fine

• 239-15 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.translational-medicine.com/content/10/1/239/abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 10 (literal)

Rivista

• Journal of translational medicine (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Cellular Biology and Neurobiology Institute, CNR, via del Fosso di Fiorano 64, 00143, Rome, Italy ; Institute of Translational Pharmacology, National Research Council (CNR), via Fosso del Cavaliere 100, 00136, Rome, Italy (literal)

Titolo

• Nerve growth factor: from the early discoveries to the potential clinical use (literal)

Abstract

• The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells. From a translational standpoint, the action of NGF on cholinergic neurons of the basal forebrain and on sensory neurons in dorsal root ganglia first gained researcher's attention, in view of possible clinical use in Alzheimer's disease patients and in peripheral neuropathies respectively. The translational and clinical research on NGF have, since then, enlarged the spectrum of diseases that could benefit from NGF treatment, at the same time highlighting possible limitations in the use of the neurotrophin as a drug. In this review we give a comprehensive account for almost all of the clinical trials attempted until now by using NGF. A perspective on future development for translational research on NGF is also discussed, in view of recent proposals for innovative delivery strategies and/or for additional pathologies to be treated, such as ocular and skin diseases, gliomas, traumatic brain injuries, vascular and immune diseases. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• Traslazionalità di approcci terapeutici integrativi (ME.P04.009.004) (Modulo)

Autore CNR

• LUIGI MANNI (Unità di personale interno)
• LUIGI ALOE (Unità di personale esterno)
• Maria Luisa Rocco (Persona)

Incoming links:

Autore CNR di

• LUIGI MANNI (Unità di personale interno)
• Maria Luisa Rocco (Persona)
• LUIGI ALOE (Unità di personale esterno)

Prodotto

• Traslazionalità di approcci terapeutici integrativi (ME.P04.009.004) (Modulo)
• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of translational medicine (Rivista)