Over-expression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition (Articolo in rivista)

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  • Over-expression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/oncsis.2012.20 (literal)
Alternative label
  • Pellecchia, Annamaria; Pescucci, Chiara; De Lorenzo, Emanuele; Luceri, Cristina; Passaro, Nunzia; Sica, Michela; Notaro, Rosario; De Angioletti, Maria (2012)
    Over-expression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition
    in Oncogenesis; Nature Publishing Group, New York (Stati Uniti d'America); Macmillan Publisher Ltd, London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pellecchia, Annamaria; Pescucci, Chiara; De Lorenzo, Emanuele; Luceri, Cristina; Passaro, Nunzia; Sica, Michela; Notaro, Rosario; De Angioletti, Maria (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Note
  • ubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • ICCOM - National Council of Research, Sesto Fiorentino, Florence, Italy Cancer Genetics and Gene Transfer Laboratory, Core Research Laboratory, Istituto Toscano Tumori, AOUC, Florence, Italy Department of Pharmacology, University of Florence, Florence, Italy (literal)
Titolo
  • Over-expression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition (literal)
Abstract
  • The discovery of translocations that involve one of the genes of the ETS family (ERG, ETV1, ETV4, ETV5) has been a major advance in understanding the molecular basis of prostate cancer. Each one of these translocations results in deregulated expression of one of the ETS proteins. Here we focus on the mechanism whereby over-expression of the ETV4 gene mediates oncogenesis in the prostate. By siRNA technology we show that ETV4 inhibition in the PC3 cancer cell line reduces not only cell mobility and anchorage-independent growth, but also cell proliferation, cell cycle progression and tumor growth in a xenograft model. Conversely, ETV4 over-expression in the non-malignant cell line RWPE increases anchorage-independent growth, cell mobility, and cell proliferation, which is probably mediated by down-regulation of p21, producing accelerated progression through the cell cycle. ETV4 over-expression is associated with changes in the pattern of E- cadherin and N-cadherin expression; the cells also become spindle-shaped, and these changes are characteristic of the so-called epithelial to mesenchymal transition (EMT). In RWPE cells over-expressing ETV4 EMT results from a marked increase in EMT-specific transcription factors such as Twist1, Slug1, Zeb1 and Zeb2. Thus, whereas ETV4 shares with the other ETS proteins (ERG, ETV5 and ETV1) a major role in invasiveness and cell migration, it emerges as unique in that it increases at the same time also the rate of proliferation of prostate cancer cells. Considering the wide spectrum in the clinical course of patients with prostate cancer, it may be highly relevant that ETV4 is capable of inducing most and perhaps all of the features that make a tumor aggressive. (literal)
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