http://www.cnr.it/ontology/cnr/individuo/prodotto/ID193401
Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers (Articolo in rivista)
- Type
- Label
- Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/srep00441 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Zapperi S.; La Porta C.A.M. (literal)
- Pagina inizio
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.nature.com/srep/2012/120607/srep00441/full/srep00441.html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1 : CNR-IENI, Via R. Cozzi 53, 20125 Milano, Italy /
1 : ISI Foundation, Via Alassio 11/C, 10126 Torino, Italy /
3 : Department of Life Sciences, University of Milano, via Celoria 26, 20133 Milano, Italy (literal)
- Titolo
- Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers (literal)
- Abstract
- The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations. Experiments report that sorted cancer cell populations after some time tend to express again all the original markers, leading to the hypothesis of phenotypic switching, according to which cancer cells can transform stochastically into cancer stem cells. Here we explore an alternative explanation based on the hypothesis that markers are not perfect and are thus unable to identify all cancer stem cells. Our analysis is based on a mathematical model for cancer cell proliferation that takes into account phenotypic switching, imperfect markers and error in the sorting process. Our conclusion is that the observation of reversible expression of surface markers after sorting does not provide sufficient evidence in support of phenotypic switching. (literal)
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