Association study of NACP-REP1 polymorphism and Parkinson's disease (Abstract in rivista)

Type
Label
  • Association study of NACP-REP1 polymorphism and Parkinson's disease (Abstract in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • P Spadafora, G Annesi, P Tarantino, EV De Marco, D Civitelli, S Carrideo, IC Cirò Candiano, PASQUA A, N Romeo, M Caracciolo, G Arabia, P Pugliese, M Zappia, F Annesi, A Quattrone (2003)
    Association study of NACP-REP1 polymorphism and Parkinson's disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • P Spadafora, G Annesi, P Tarantino, EV De Marco, D Civitelli, S Carrideo, IC Cirò Candiano, PASQUA A, N Romeo, M Caracciolo, G Arabia, P Pugliese, M Zappia, F Annesi, A Quattrone (literal)
Pagina inizio
  • s-178 (literal)
Pagina fine
  • s-179 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
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  • Clinica Neurologica, Università di Catanzaro, Via Campanella, Catanzaro, Italy ; Istituto di Scienze Neurologiche, CNR, Piano Lago di Mangone (CS), Italy ; Dipartimento di Neuroscienze, Università di Messina, Italy (literal)
Titolo
  • Association study of NACP-REP1 polymorphism and Parkinson's disease (literal)
Abstract
  • We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD. (literal)
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