http://www.cnr.it/ontology/cnr/individuo/prodotto/ID192706
Association study of NACP-REP1 polymorphism and Parkinson's disease (Abstract in rivista)
- Type
- Label
- Association study of NACP-REP1 polymorphism and Parkinson's disease (Abstract in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
P Spadafora, G Annesi, P Tarantino, EV De Marco, D Civitelli, S Carrideo, IC Cirò Candiano, PASQUA A, N Romeo, M Caracciolo, G Arabia, P Pugliese, M Zappia, F Annesi, A Quattrone (2003)
Association study of NACP-REP1 polymorphism and Parkinson's disease
(literal)
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- P Spadafora, G Annesi, P Tarantino, EV De Marco, D Civitelli, S Carrideo, IC Cirò Candiano, PASQUA A, N Romeo, M Caracciolo, G Arabia, P Pugliese, M Zappia, F Annesi, A Quattrone (literal)
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- Clinica Neurologica, Università di Catanzaro, Via Campanella, Catanzaro, Italy ; Istituto di Scienze Neurologiche, CNR, Piano Lago di Mangone (CS), Italy ; Dipartimento di Neuroscienze, Università di Messina, Italy (literal)
- Titolo
- Association study of NACP-REP1 polymorphism and Parkinson's disease (literal)
- Abstract
- We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and
10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD. (literal)
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