http://www.cnr.it/ontology/cnr/individuo/prodotto/ID192384

RARE HLA ALLELES AND IMPACT ON HLA-MATCHING IN KIDNEY TRANSPLANTATION. (Abstract/Poster in rivista)

Type

Abstract/Poster in rivista (Classe)
Prodotto della ricerca (Classe)

Label

RARE HLA ALLELES AND IMPACT ON HLA-MATCHING IN KIDNEY TRANSPLANTATION. (Abstract/Poster in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Alternative label

Giuseppina Ozzella 1, Elvira Poggi 1, Valentina Imbroglini 2, Luisa Mazzitelli 2, Martina Carducci 2, Domenico Adorno 2, Antonina Piazza 1 (2012)
RARE HLA ALLELES AND IMPACT ON HLA-MATCHING IN KIDNEY TRANSPLANTATION.
(literal)

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Giuseppina Ozzella 1, Elvira Poggi 1, Valentina Imbroglini 2, Luisa Mazzitelli 2, Martina Carducci 2, Domenico Adorno 2, Antonina Piazza 1 (literal)

Pagina inizio

76 (literal)

Pagina fine

76 (literal)

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poster (literal)

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73 (literal)

Rivista

Human immunology (Rivista)

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1 (literal)

Note

Abstract (literal)
Google Scholar (literal)

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1 Institute of Translational Pharmacology Unit of Rome S. Camillo Hospital, National Council of Researches, Rome, Italy; 2 Regional Transplant Center of Lazio, Tor Vergata University of Rome, Rome, Italy. (literal)

Titolo

RARE HLA ALLELES AND IMPACT ON HLA-MATCHING IN KIDNEY TRANSPLANTATION. (literal)

Abstract

Aim: In kidney transplant candidates an increase of the rare HLA alleles due to immigration flow growth was observed. The high polymorphism of HLA alleles should make difficult the finding a suitable donor, especially in sensitized patients. In fact, humoral immune response often determines the production of a broad antibodies pattern due to the recognition of mismatched HLA epitopes. Methods: We analyzed the presence of rare HLA alleles in 934 renal transplant candidates, routinely typed by SSP/-rSSO method and, on the basis of HLA antibody identification, the typing was enlarged to pertinent HLA loci. Rare alleles were confirmed by high resolution SSP method. The allele frequencies (af) were assessed by direct count and the potential immunogenic epitopes were assessed comparing amino acid sequences of these alleles with the corresponding alleles by an online database. Results: A total of 20 rare alleles (2.1%) was found and some of these are give below: B/14:06:01 (af = 1.96%, Caucasian patient), differs from other B/14 alleles by Tryptophan?Arginine substitution at position 97; B/15:38 (af = 1.00%, Asian patient), differs from other B/15 alleles by Histidine?Tyrosine substitution at position 171; B/18:18, (af = 0.58%, Caucasian patient), differs from other B/18 alleles by Serine?Tyrosine substitutions at position 99; B/51:07 (af = 0.58%, Caucasian patient), differs from other B/51 alleles by Serine? Phenylalanine substitution at position 67; DRB1/14:16 (af = 0.93%, Caucasian patient) differs from other DRB1/14 alleles by Leucine?Isoleucine, Arginine?Aspartic acid, Arginine?Glutamic acid, Glutamic acid?Alanine substitutions at positions 67, 70, 71, 74; DQB1/03:05 (af = 0.88%, Caucasian patient), differs from other DQB1/03 alleles by Leucine?Glycine substitution at position 26. Conclusions: The presence of rare HLA alleles suggests a new policy of HLA typing providing amino acid sequence information and the application of an epitope-based HLA-matching to improve clinical course of kidney transplantation. (literal)

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