Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/acel.12009 (literal)

Alternative label

• Carmela Matrone 1,2; Siro Luvisetto 1; Luca R. La Rosa 1; Robert Tamayev 3; Annabella Pignataro 1,4; Nadia Canu 1,5; Li Yang 6; Alessia P. M. Barbagallo 3; Fabrizio Biundo 3; Franco Lombino 3; Hui Zheng 6; Martine Ammassari-Teule 1,4; Luciano D'Adamio 3 (2012)
  Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance
  in Aging cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carmela Matrone 1,2; Siro Luvisetto 1; Luca R. La Rosa 1; Robert Tamayev 3; Annabella Pignataro 1,4; Nadia Canu 1,5; Li Yang 6; Alessia P. M. Barbagallo 3; Fabrizio Biundo 3; Franco Lombino 3; Hui Zheng 6; Martine Ammassari-Teule 1,4; Luciano D'Adamio 3 (literal)

Pagina inizio

• 1084 (literal)

Pagina fine

• 1093 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Aging cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 CNR - National Research Council, Cell Biology and Neurobiology Institute, Rome, 00143, Italy. 2 Department of Medical Biochemistry, University of Aarhus, 8000, Aarhus C, Denmark. 3 Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, NY, 10461, USA. 4 Santa Lucia Foundation, Experimental Neurology Unit, Rome, 00143, Italy. 5 Department of Systems Medicine, University of Tor Vergata, Rome, 00133, Italy. 6 Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA. (literal)

Titolo

• Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance (literal)

Abstract

• Processing of Abeta-precursor protein (APP) plays an important role in Alzheimer's disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the (682) YENPTY(687) motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Y(682) to Gly (APP(YG/YG) mice). This mutation alters the processing of APP and TrkA signaling and leads to postnatal lethality and neuromuscular synapse defects when expressed on an APP-like protein 2 KO background. This evidence prompted us to characterize further the APP(YG/YG) mice. Here, we show that APP(YG/YG) mice develop aging-dependent decline in cognitive and neuromuscular functions, a progressive reduction in dendritic spines, cholinergic tone, and TrkA levels in brain regions governing cognitive and motor functions. These data are consistent with our previous findings linking NGF and APP signaling and suggest a causal relationship between altered synaptic connectivity, cholinergic tone depression and TrkA signaling deficit, and cognitive and neuromuscular decline in APP(YG/YG) mice. The profound deficits caused by the Y(682) mutation underscore the biological importance of APP and indicate that APP(YG/YG) are a valuable mouse model to study APP functions in physiological and pathological processes. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Autore CNR

• ANNE MARIE TEULE (Persona)
• Luca Rosario La Rosa (Persona)
• SIRO LUVISETTO (Persona)
• nadia canu (Persona)

Insieme di parole chiave

• Keywords of "Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNE MARIE TEULE (Persona)
• SIRO LUVISETTO (Persona)
• nadia canu (Persona)
• Luca Rosario La Rosa (Persona)

Prodotto

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)
• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Aging cell (Rivista)

Insieme di parole chiave di

• Keywords of "Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance" (Insieme di parole chiave)