Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy (Articolo in rivista)

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  • Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Faye M. Drawnel,1 Dagmar Wachten,1,2 Jeffery D. Molkentin,3 Marjorie Maillet,3 Jan Magnus Aronsen,4,5 Fredrik Swift,4 Ivar Sjaastad,4 Ning Liu,6 Daniele Catalucci,7,8 Katsuhiko Mikoshiba,9 Chihiro Hisatsune,9 Hanneke Okkenhaug,1 Simon R. Andrews,1 Martin D. Bootman,1 and H. Llewelyn Roderick1,10 (2012)
    Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
    in The journal of cell biology (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Faye M. Drawnel,1 Dagmar Wachten,1,2 Jeffery D. Molkentin,3 Marjorie Maillet,3 Jan Magnus Aronsen,4,5 Fredrik Swift,4 Ivar Sjaastad,4 Ning Liu,6 Daniele Catalucci,7,8 Katsuhiko Mikoshiba,9 Chihiro Hisatsune,9 Hanneke Okkenhaug,1 Simon R. Andrews,1 Martin D. Bootman,1 and H. Llewelyn Roderick1,10 (literal)
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Note
  • PubMed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 2Department of Molecular Sensory Systems, Center of Advanced European Studies and Research, 53175 Bonn, Germany 3Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 4Institute for Experimental Medical Research, Faculty of Medicine 5Bjørknes College, 0456 Oslo, Norway 6Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390 7Humanitas Clinical and Research Center, 20089 Rozzano, Milan, Italy 8Institute of Genetic and Biomedical Research, Milan Section, National Research Council, 20138 Milan, Italy 9Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 531-0198, Japan 10Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, England, UK (literal)
Titolo
  • Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy (literal)
Abstract
  • Inositol 1,4,5'-triphosphate receptor II (IP(3)RII) calcium channel expression is increased in both hypertrophic failing human myocardium and experimentally induced models of the disease. The ectopic calcium released from these receptors induces pro-hypertrophic gene expression and may promote arrhythmias. Here, we show that IP(3)RII expression was constitutively restrained by the muscle-specific miRNA, miR-133a. During the hypertrophic response to pressure overload or neurohormonal stimuli, miR-133a down-regulation permitted IP(3)RII levels to increase, instigating pro-hypertrophic calcium signaling and concomitant pathological remodeling. Using a combination of in vivo and in vitro approaches, we demonstrated that IP(3)-induced calcium release (IICR) initiated the hypertrophy-associated decrease in miR-133a. In this manner, hypertrophic stimuli that engage IICR set a feed-forward mechanism in motion whereby IICR decreased miR-133a expression, further augmenting IP(3)RII levels and therefore pro-hypertrophic calcium release. Consequently, IICR can be considered as both an initiating event and a driving force for pathological remodeling. (literal)
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