http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19199
Enhanced cognitive performance of dopamine D3 receptor\" knock-out\" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. (Articolo in rivista)
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- Enhanced cognitive performance of dopamine D3 receptor\" knock-out\" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Micale V.; Cristino L.; Tamburella A.; Petrosino S.; Leggio GM.; Di Marzo V.; Drago F. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Micale V.; Leggio GM.; Drago F.:Department of Experimental and Clinical Pharmacology, University of Catania Medical School, V.le A. Doria 6, 95125 Catania, Italy
Cristino L.: Endocannabinoid Research Group, Istituto di Cibernetica \"Edoardo Caianiello\", Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
Petrosino S.; Di Marzo V.:Endocannabinoid Research Group, Istituto di Chimica Biololecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy (literal)
- Titolo
- Enhanced cognitive performance of dopamine D3 receptor\" knock-out\" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. (literal)
- Abstract
- Increasing evidence suggests a pivotal role of the D3 receptor (D3R) in cognitive processes and the involvement of endocannabinoid/endovanilloid signaling in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease. This study was undertaken to investigate both the basal and beta-amyloid peptide 1-42 (BAP 1-42)-impaired cognitive performance of D3R((-/-)) mice, and the role therein of endocannabinoids/endovanilloids. D3R((-/-)) mice were either untreated or injected i.c.v. with 400 pMol BAP 1-42 or vehicle to be tested 14 days later in a step-through passive-avoidance paradigm. The CB(1) receptor antagonist, rimonabant (1mg/kg), or the transient receptor potential vanilloid-type 1 channel (TRPV1) antagonist SB366791, were injected intraperitoneally for 11 or 7 days. The retention test was performed 1, 7 and 14 days after the learning trial. Wild-type (WT) mice were subjected to the same procedures. D3R((-/-)) mice exhibited a better basal cognitive performance as compared to WT mice (p<0.001), which was reversed by TRPV1 antagonism. BAP 1-42 induced a pronounced worsening of the passive-avoidance response in all tests and in both genotypes (p<0.001). Rimonabant treatment never affected the cognitive performance of healthy mice, but fully counteracted BAP 1-42-induced amnesic effects in both D3R((-/-)) and WT mice only when administered for 11 days, whereas, when administered for 7 days, only transiently affected WT mice and caused more prolonged cognitive ameliorations in D3R((-/-)) mice. These results support the involvement of D3R and TRPV1 in cognitive processes and the concept that A beta peptides inhibit memory retention in mice through the involvement of endocannabinoids. (literal)
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