Suppression by gamma-hydroxybutyric acid of \"alcohol deprivation effect\" in rats: Preclinical evidence of its anti-relapse properties (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Suppression by gamma-hydroxybutyric acid of \"alcohol deprivation effect\" in rats: Preclinical evidence of its anti-relapse properties (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3389/fpsyt.2012.00095 (literal)

Alternative label

• Colombo G., Carai M.A.M., Gessa G.L. (2012)
  Suppression by gamma-hydroxybutyric acid of "alcohol deprivation effect" in rats: Preclinical evidence of its anti-relapse properties
  in Frontiers in Psychiatry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Colombo G., Carai M.A.M., Gessa G.L. (literal)

Pagina inizio

• 95 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Frontiers in Psychiatry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA), Italy (literal)

Titolo

• Suppression by gamma-hydroxybutyric acid of \"alcohol deprivation effect\" in rats: Preclinical evidence of its anti-relapse properties (literal)

Abstract

• Gamma-hydroxybutyric acid (GHB) reduces (a) alcohol intake and alcohol motivational properties in alcohol-preferring rats and (b) alcohol drinking and craving for alcohol in human alcoholics. The present study was designed to extend to relapse-like drinking the capacity of GHB to suppress different alcohol-related behaviors in alcohol-preferring rats. The \"alcohol deprivation effect\", defined as the temporary increase in alcohol intake occurring in laboratory animals after a period of alcohol deprivation, was used as model of alcohol relapse. Acute administration of non-sedative doses of GHB (0, 100, 200, and 300 mg/kg, i.p.) resulted in the complete suppression of the extra-amount of alcohol consumed by Sardinian alcohol-preferring (sP) rats during the first hour of re-access to alcohol after a 14-day period of deprivation. These data demonstrate that GHB suppressed relapse-like drinking in a rat model of excessive alcohol consumption. (literal)

Prodotto di

• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• GIAN LUIGI GESSA (Unità di personale esterno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Suppression by gamma-hydroxybutyric acid of \"alcohol deprivation effect\" in rats: Preclinical evidence of its anti-relapse properties" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Frontiers in Psychiatry (Rivista)

Insieme di parole chiave di

• Keywords of "Suppression by gamma-hydroxybutyric acid of \"alcohol deprivation effect\" in rats: Preclinical evidence of its anti-relapse properties" (Insieme di parole chiave)