New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c1dt11519g (literal)

Alternative label

• Bruno Demoro, Cynthia Sarniguet, Roberto Sanchez-Delgado, Miriam Rossi, Daniel Liebowitz, Caruso F, Claudio Olea-Azar, Virtudes Moreno, Andrea Medeiros, Marcelo A. Comini, Luca Otero, Dinorah Gambino (2012)
  New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.
  in Dalton transactions (2003. Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bruno Demoro, Cynthia Sarniguet, Roberto Sanchez-Delgado, Miriam Rossi, Daniel Liebowitz, Caruso F, Claudio Olea-Azar, Virtudes Moreno, Andrea Medeiros, Marcelo A. Comini, Luca Otero, Dinorah Gambino (literal)

Pagina inizio

• 1534 (literal)

Pagina fine

• 1543 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• articolo accessibile dall'editore dietro pagamento (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://pubs.rsc.org/en/Content/ArticleLanding/2012/DT/c1dt11519g (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• Dalton transactions (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Cátedra de Química Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República (UdelaR), Gral. Flores 2124, 11800, Montevideo, Uruguay; Chemistry Department, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, New York 11210, USA; Vassar College, Department of Chemistry, Poughkeepsie NY 12604 USA; Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, c/o Università di Roma La Sapienza, Vecchio Istituto Chimico, P.le Aldo Moro 5, 00185 Rome, Italy; Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago, Chile; Departamento de Química Inorgánica, Universitat Barcelona, Martí i Franquès 1-11,08028 Barcelona, Spain; Group Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Mataojo 2020, CP 11400, Montevideo, Uruguay. (literal)

Titolo

• New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. (literal)

Abstract

• In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium compounds with bioactive nitrofuran containing thiosemicarbazones (L) as co-ligands were obtained. Four ruthenium(II) complexes with the formula [Ru(2)(p-cymene)(2)(L)(2)]X(2), where X = Cl or PF(6), were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods. Two of the complexes show significant in vitro growth inhibition activity against Trypanosoma brucei brucei and are highly selective towards trypanosomal cells with respect to mammalian cells (J774 murine macrophages). These promising results make the title organoruthenium compounds good lead candidates for further developments towards potential antitrypanosomal organometallic drugs. (literal)

Prodotto di

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Antiossidanti per uso farmaceutico, cosmetico e alimentare (PM.P01.011.006) (Modulo)

Autore CNR

• FRANCESCO CARUSO (Persona)

Insieme di parole chiave

• Keywords of "New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCO CARUSO (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Antiossidanti per uso farmaceutico, cosmetico e alimentare (PM.P01.011.006) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Dalton transactions (Rivista)

Insieme di parole chiave di

• Keywords of "New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents." (Insieme di parole chiave)