http://www.cnr.it/ontology/cnr/individuo/prodotto/ID191831

Increased Nerve Growth Factor (NGF) serum levels in top athletes (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Increased Nerve Growth Factor (NGF) serum levels in top athletes (Articolo in rivista) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1097/JSM.0b013e31827ee6d5 (literal)

Alternative label

Matteo Bonini Daniela Fioretti Vittorio Sargentini Stefano Del Giacco Monica Rinaldi Carlo Tranquilli Sergio Bonini (2013)
Increased Nerve Growth Factor (NGF) serum levels in top athletes
in Clinical Journal of Sport Medicine
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Matteo Bonini Daniela Fioretti Vittorio Sargentini Stefano Del Giacco Monica Rinaldi Carlo Tranquilli Sergio Bonini (literal)

Pagina inizio

228 (literal)

Pagina fine

231 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

23 (literal)

Rivista

Clinical Journal of Sport Medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

Scopus (literal)
PubMed (literal)
ISI Web of Science (WOS) (literal)
Google Scholar (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Medicine - Lung Function Unit, \"Sapienza\" University of Rome, Italy Institute of Translational Pharmacology, Department of Medicine, National Research Council, Rome, Italy ASL Roma A, Rome, Italy Department of Medical Science \"M. Aresu\", University of Cagliari, Italy Institute of Medicine and Sport Science \"A. Venerando\" Italian National Olympic Committee, Rome, Italy Department of Internal Medicine, Second University of Naples, Italy (literal)

Titolo

Increased Nerve Growth Factor (NGF) serum levels in top athletes (literal)

Abstract

OBJECTIVE: The nerve growth factor (NGF) is the main neurotrophin, which, besides being an important growth factor for nerves, plays an important role as a mediator of inflammation. Nerve growth factor has been shown to increase in relation to stress stimuli and in allergic diseases in humans as well as after physical exercise in animal models. This study aims at evaluating NGF serum levels in top athletes, a population sample in which allergic and neuro-immune diseases are reported with a significantly increased prevalence. DESIGN: Observational, cross-sectional, multicenter study. SETTING: Institutional, tertiary care. PARTICIPANTS: Ninety-six Italian pre-Olympic athletes (44 allergic and 52 nonallergic) and 49 matched controls selected within the Italian National Olympic delegation (n = 435). INDEPENDENT VARIABLES: Nerve growth factor serum levels determined through an enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES: Parametric or nonparametric tests were used for comparing NGF serum levels among different study groups depending on value distributions. RESULTS: Nerve growth factor serum levels were significantly higher in athletes than in controls independently from the presence of allergy. Nerve growth factor mean values were 368.3 ± 776.3 pg/mL in the sample of athletes and 174.1 ± 483.7 pg/mL in the control group (P < 0.001). CONCLUSIONS: This is the first study showing that intense and prolonged physical exercise is associated with an increase of NGF serum levels in athletes. Whether the increased NGF production might be linked to the prevalent Th2 response observed in allergic diseases and after physical exercise and whether it might be related to the patophysiology of neuro-immune disorders as such amyotrophic lateral sclerosis, reported with a higher prevalence in athletes, should deserve further investigations. (literal)

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