Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma (Articolo in rivista)

Type
Label
  • Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1309/AJCPRXHNJQLO09QA (literal)
Alternative label
  • Cenci Tonia; Martini Maurizio; Montano Nicola; D'Alessandris Quintino G.; Falchetti Maria Laura; Annibali Daniela; Savino Mauro; Bianchi Federico ; Pierconti Francesco; Nasi Sergio; Pallini Roberto; Larocca Luigi Maria (2012)
    Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma
    in American journal of clinical pathology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cenci Tonia; Martini Maurizio; Montano Nicola; D'Alessandris Quintino G.; Falchetti Maria Laura; Annibali Daniela; Savino Mauro; Bianchi Federico ; Pierconti Francesco; Nasi Sergio; Pallini Roberto; Larocca Luigi Maria (literal)
Pagina inizio
  • 390 (literal)
Pagina fine
  • 396 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 138 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Anatomia Patologica, Universit√† Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Roma, Italy. (literal)
Titolo
  • Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma (literal)
Abstract
  • Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways.Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways. (literal)
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