Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Simmer F, Brinkman AB, Assenov Y, Matarese F, Kaan A, Sabatino L, Villanueva A, Huertas D, Esteller M, Lengauer T, Bock C, Colantuoni V, Altucci L, Stunnenberg HG. (2012)
  Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues.
  in Epigenetics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simmer F, Brinkman AB, Assenov Y, Matarese F, Kaan A, Sabatino L, Villanueva A, Huertas D, Esteller M, Lengauer T, Bock C, Colantuoni V, Altucci L, Stunnenberg HG. (literal)

Pagina inizio

• 1355 (literal)

Pagina fine

• 1367 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7(12) (literal)

Rivista

• Epigenetics (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Molecular Biology; Faculty of science; Nijmegen centre for Molecular Life sciences; Radboud University; Nijmegen, The Netherlands; Max planck Institute for Informatics; saarbrücken, Germany; Department of Biological, Geological and Environmental sciences; University of sannio; Benevento, Italy; Catalan Institute of Oncology; Bellvitge Biomedical Research Institute; Barcelona, catalonia spain; Cancer Epigenetics and Biology program; Bellvitge Biomedical Research Institute; Barcelona, catalonia spain; ceMM Research center for Molecular Medicine of the austrian academy of sciences; Vienna, austria; Department of Laboratory Medicine; Medical University of Vienna; Vienna, Austria; IGB-cNR; Napoli, Italy; Department of General pathology; seconda Università degli studi di Napoli; Napoli, Italy (literal)

Titolo

• Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. (literal)

Abstract

• Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potential biomarkers for CRC diagnosis. Hypermethylation in the tumor samples was enriched at CpG islands and gene promoters, while hypomethylation was distributed throughout the genome. Using epigenetic data from human embryonic stem cells, we show that frequently hypermethylated regions coincide with bivalent loci in human embryonic stem cells. DNA methylation is commonly thought to lead to gene silencing; however, integration of publically available gene expression data indicates that 75% of the frequently hypermethylated genes were most likely already lowly or not expressed in normal tissue. Collectively, our study provides genome-wide DNA methylation maps of CRC, comprehensive lists of DMRs, and gives insights into the role of aberrant DNA methylation in CRC formation. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR

• Lucia Altucci (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR di

• Lucia Altucci (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Epigenetics (Rivista)