O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/1746-6148-8-218 (literal)

Alternative label

• Altamura G, Strazzullo M, Corteggio A, Francioso R, Roperto F, D'Esposito M, Borzacchiello G. (2012)
  O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis.
  in BMC veterinary research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Altamura G, Strazzullo M, Corteggio A, Francioso R, Roperto F, D'Esposito M, Borzacchiello G. (literal)

Pagina inizio

• 218 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8(1) (literal)

Rivista

• BMC veterinary research (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute for Animal Production System in Mediterranean Environment, National Research Council, Via Argine, 1085 80147 Naples, Italy Institute of Genetic and Biophysics ABT, National Research Council, Via P.Castellino 111, 80131 Naples, Italy IRCCS Neuromed, Pozzilli, Italy Department of Pathology and Animal health, University of Naples Federico II, Via Veterinaria, 1-80137 Napoli, Italy (literal)

Titolo

• O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis. (literal)

Abstract

• BACKGROUND: Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to neoplastic skin lesions in equids termed sarcoids. The equine sarcoid is considered to be the most common equine cutaneous tumour worldwide for which no effective therapy is available. Very little is known about the molecular mechanisms underlying tumourigenesis, although genes contributing to sarcoid development have been identified. Several studies associate the development of cancer to the loss of function of a number of oncosuppressor genes. In this study the putative role of O6-methylguanine-DNA methyltrasferase (MGMT) was investigated for sarcoids. The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissues. In addition, the DNA methylation profile was analysed to assess the role of epigenetic mechanism in regulation of MGMT expression. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)

Autore CNR

• MAURIZIO D'ESPOSITO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)

Autore CNR di

• MAURIZIO D'ESPOSITO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• BMC veterinary research (Rivista)