Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Bell R.L., Sable H.J.K., Colombo G., Hyytiä P., Rodd Z.A., Lumeng L. (2012)
  Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity
  in Pharmacology, biochemistry and behavior
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bell R.L., Sable H.J.K., Colombo G., Hyytiä P., Rodd Z.A., Lumeng L. (literal)

Pagina inizio

• 119 (literal)

Pagina fine

• 155 (literal)

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• 103 (literal)

Rivista

• Pharmacology, biochemistry and behavior (Rivista)

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• 37 (literal)

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• 1 (literal)

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• Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Psychology, University of Memphis, Memphis, Tennessee, USA; Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato, Italy; Institute of Biomedicine, University of Helsinki, Finland; Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA (literal)

Titolo

• Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity (literal)

Abstract

• The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption phenotype. The behavioral and neurochemical phenotypes of these rat lines are reviewed and placed in the context of the clinical literature. The paper presents behavioral models for assessing the efficacy of pharmaceuticals for the treatment of alcohol abuse and dependence in rodents, with particular emphasis on rats. Drugs that have been tested for their effectiveness in reducing alcohol/ethanol consumption and/or self-administration by these rat lines and their putative site of action are summarized. The paper also presents some current and future directions for developing pharmacological treatments targeting alcohol abuse and dependence. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacology, biochemistry and behavior (Rivista)

Insieme di parole chiave di

• Keywords of "Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity" (Insieme di parole chiave)