Interaction of Cisplatin with Human Superoxide Dismutase (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Interaction of Cisplatin with Human Superoxide Dismutase (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/ja211591n (literal)

Alternative label

• Lucia Banci; Ivano Bertini; Olga Blazevits; Vito Calderone; Francesca Cantini; Jiafei Mao;, Angela Trapananti; Miguela Vieru; Ilaria Amori; Mauro Cozzolino; and Maria Teresa Carrì (2012)
  Interaction of Cisplatin with Human Superoxide Dismutase
  in Journal of the American Chemical Society (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lucia Banci; Ivano Bertini; Olga Blazevits; Vito Calderone; Francesca Cantini; Jiafei Mao;, Angela Trapananti; Miguela Vieru; Ilaria Amori; Mauro Cozzolino; and Maria Teresa Carrì (literal)

Pagina inizio

• 7009 (literal)

Pagina fine

• 7014 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 134 (literal)

Rivista

• Journal of the American Chemical Society (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy; Univ Florence, Dept Chem, I-50019 Florence, Italy; Fdn Farmacogenom FiorGen Onlus, I-50019 Sesto Fiorentino, Italy Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy; Univ Florence, Dept Chem, I-50019 Florence, Italy; Fdn Farmacogenom FiorGen Onlus, I-50019 Sesto Fiorentino, Italy Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy; Univ Florence, Dept Chem, I-50019 Florence, Italy; Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy; Fdn Farmacogenom FiorGen Onlus, I-50019 Sesto Fiorentino, Italy Fdn Santa Lucia, IRCCS, Rome, Italy Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy CNR-IOM-OGG c/o ESRF, F-38043 Grenoble, France Univ Florence, Magnet Resonance Ctr CERM, I-50019 Florence, Italy; Univ Florence, Dept Chem, I-50019 Florence, Italy Fdn Santa Lucia, IRCCS, Rome, Italy Fdn Santa Lucia, IRCCS, Rome, Italy Fdn Santa Lucia, IRCCS, Rome, Italy; Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy (literal)

Titolo

• Interaction of Cisplatin with Human Superoxide Dismutase (literal)

Abstract

• cis-Diamminedichloroplatinum(II) (cisplatin) is able to interact with human superoxide dismutase (hSOD1) in the disulfide oxidized apo form with a dissociation constant of 37 ± 3 ?M through binding cysteine 111 (Cys111) located at the edge of the subunit interface. It also binds to Cu2-Zn2 and Zn2-Zn2 forms of hSOD1. Cisplatin inhibits aggregation of demetalated oxidized hSOD1, and it is further able to dissolve and monomerize oxidized hSOD1 oligomers in vitro and in cell, thus indicating its potential as a leading compound for amyotrophic lateral sclerosis. (literal)

Prodotto di

• Sviluppo di strumentazione e di metodologie sperimentali avanzate per lo studio delle proprieta strutturali dei materiali con raggi X da sincrotrone (MD.P04.007.001) (Modulo)

Autore CNR

• ANGELA TRAPANANTI (Persona)
• MAURO COZZOLINO (Unità di personale interno)

Incoming links:

Autore CNR di

• MAURO COZZOLINO (Unità di personale interno)
• ANGELA TRAPANANTI (Persona)

Prodotto

• Sviluppo di strumentazione e di metodologie sperimentali avanzate per lo studio delle proprieta strutturali dei materiali con raggi X da sincrotrone (MD.P04.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of the American Chemical Society (Rivista)