http://www.cnr.it/ontology/cnr/individuo/prodotto/ID189688

Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus. (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1371/journal.pone.0048334 (literal)

Alternative label

Stefano Falone, Antonella D'Alessandro, Alessandro Mirabilio, Marisa Cacchio, Carmine Di Ilio, Silvia Di Loreto, Fernanda Amicarelli (2012)
Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus.
in PloS one; Hemachandra Reddy,, Oregon (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Stefano Falone, Antonella D'Alessandro, Alessandro Mirabilio, Marisa Cacchio, Carmine Di Ilio, Silvia Di Loreto, Fernanda Amicarelli (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

7 (literal)

Rivista

PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

10 (literal)

Note

Scopus (literal)
PubMed (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Basic and Applied Biology, University of L'Aquila, L'Aquila (AQ), Italy, 2 Department of Basic and Applied Medical Sciences, University ''G. d'Annunzio'', Chieti Scalo (CH), Italy, Department of Biomedical Sciences, University ''G. d'Annunzio'', Chieti Scalo (CH), Italy, 4 Institute of Translational Pharmacology (IFT) - National Research Council (CNR), L'Aquila (AQ), Italy (literal)

Titolo

Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus. (literal)

Abstract

Despite the active research in this field, molecular mechanisms underlying exercise-induced beneficial effects on brain physiology and functions are still matter of debate, especially with regard to biological processes activated by regular exercise affecting the onset and progression of hippocampal aging in individuals unfamiliar with habitual physical activity. Since such responses seem to be mediated by changes in antioxidative, antiglycative and metabolic status, a possible exercise-induced coordinated response involving redox, methylglyoxal- and sirtuin-related molecular networks may be hypothesized. In this study, hippocampi of CD1 mice undergoing the transition from mature to middle age were analyzed for redox-related profile, oxidative and methylglyoxal-dependent damage patterns, energy metabolism, sirtuin1 and glyoxalase1 expression after a 2- or 4-mo treadmill running program. Our findings suggested that the 4-mo regular running lowered the chance of dicarbonyl and oxidative stress, activated mitochondrial catabolism and preserved sirtuin1-related neuroprotection. Surprisingly, the same cellular pathways were negatively affected by the first 2 months of exercise, thus showing an interesting biphasic response. In conclusion, the duration of exercise caused a profound shift in the response to regular running within the rodent hippocampus in a time-dependent fashion. This research revealed important details of the interaction between exercise and mammal hippocampus during the transition from mature to middle age, and this might help to develop non-pharmacological approaches aimed at retarding brain senescence, even in individuals unfamiliar with habitual exercise. (literal)

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