Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0032710 (literal)

Alternative label

• Bozkurt, L.;Gobl, C.S.;Tura, A.;Chmelik, M.;Prikoszovich, T.;Kosi, L.;Wagner, O.;Roden, M.;Pacini, G.;Gastaldelli, A.;Kautzky-Willer, A. (2012)
  Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bozkurt, L.;Gobl, C.S.;Tura, A.;Chmelik, M.;Prikoszovich, T.;Kosi, L.;Wagner, O.;Roden, M.;Pacini, G.;Gastaldelli, A.;Kautzky-Willer, A. (literal)

Pagina inizio

• 32710 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/22393439 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 5, 6, 11: Unit of Gender Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria / 2: Unit of Gender Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria - Division of Feto-Maternal Medicine, Department of Gyneacology and Obstetrics, Medical University of Vienna, Vienna, Austria / 3, 9: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy / 4: High Field Magnetic Resonance Centre of Excellence, Medical University of Vienna, Vienna, Austria / 7: Chemical Laboratory Diagnostics, Clinical Institute for Medical, Medical University of Vienna, Vienna, Austria / 8: Department of Metabolic Diseases, German Diabetes Center, Leibniz Center for Diabetes Research, Institute for Clinical Diabetology, Heinrich-Heine University, Dusseldorf, Germany / 10: Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy (literal)

Titolo

• Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes (literal)

Abstract

• Background and Aims: Determinants of fatty liver (FL) might be predictive for further deterioration in insulin resistance (IR) in women with previous gestational diabetes (pGDM). The aim was to evaluate the association between pGDM, FL and future manifestation of type 2 diabetes (T2DM) by a detailed pathophysiological characterization early after pregnancy. Methods: 68 pGDM and 29 healthy controls were included 3-6 months after delivery and underwent specific metabolic assessments: status of IR was determined via oral- and intravenous-glucose-tolerance-tests with analysis of proinflammatory factors and kinetics of free-fatty-acids (FFA). According to the fatty-liver-index (FLI), pGDMs were categorized into three groups with low (FLI#20), intermediate (20,FLI,60) and high (FLI) risk for FL to assess differences in metabolic parameters at baseline as well as in the 10-year incidence for T2DM. Accuracy of FLI was proven with 1H-magneticresonance- spectroscopy. Results: FL was strongly associated with IR in pGDM. pGDM with FLI showed significantly increased interleukin-6, plasminogen-activator-inhibitor-1, tissue-plasminogen-activator, fibrinogen and increased ultrasensitive-C-reactive-protein compared to the low risk group (FLI#20). Analysis of FFA indicated a less pronounced decrease of plasma FFA levels during the oral-glucose-tolerance-test in subjects with FLI. History of GDM plus FLI conferred a high risk for the manifestation of diabetes over 10 years of observation as compared to pGDMs with FLI#20 (HR:7.85, Cl:2.02-30.5, p = 0.003). Conclusion: FL is closely linked to GDM, especially to IR and inflammation. Most interestingly, subjects with the highest FLI values showed significant alterations in FFA kinetics and a higher risk to develop T2DM in future. (literal)

Prodotto di

• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• GIOVANNI PACINI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)
• AMALIA GASTALDELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• AMALIA GASTALDELLI (Persona)
• GIOVANNI PACINI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)

Insieme di parole chiave di

• Parole chiave di "Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes" (Insieme di parole chiave)