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Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses (Articolo in rivista)
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- Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses (Articolo in rivista) (literal)
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- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.etap.2011.09.008 (literal)
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Mita L; Baldi A.; Diano N.; Viggiano E.; Portaccio M.; Nicolucci C.; Grumiro L.; Menale C.; Mita, D.G.; Spugnini E.P.; Viceconte R.; Citro G.; Pierantoni R.; Sica V.; Marino M.; Signorile P.G.; Bianco M. (2012)
Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses
in Environmental toxicology and pharmacology
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mita L; Baldi A.; Diano N.; Viggiano E.; Portaccio M.; Nicolucci C.; Grumiro L.; Menale C.; Mita, D.G.; Spugnini E.P.; Viceconte R.; Citro G.; Pierantoni R.; Sica V.; Marino M.; Signorile P.G.; Bianco M. (literal)
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- Natl Inst Biostruct & Biosyst INBB, I-00136 Rome, Italy
Univ Naples 2, Dept Expt Med, I-80138 Naples, Italy
Univ Naples 2, Dept Biochem, I-80138 Naples, Italy
Fdn Italiana Endometriosi, Rome, Italy
CNR, Inst Genet & Biophys ABT, I-80131 Naples, Italy
Regina Elena Inst Canc Res, SAFU Dept, I-00144 Rome, Italy
Univ Naples 2, Dept Gen Pathol, I-80138 Naples, Italy
Univ Roma Tre, I-00146 Rome, Italy (literal)
- Titolo
- Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses (literal)
- Abstract
- Pregnant adult Balb-C mice were exposed daily to two different doses of Bisphenol A (BPA) by subcutaneous injection beginning on gestational day 1 through the seventh day after delivery. The mothers were sacrificed on postpartum day 21, and the offspring were sacrificed at 3 months of age. Control mice were subjected to the same experimental protocol but received saline injections.
The liver, muscles, hindbrain and forebrain of the offspring were dissected and processed using HPLC to assess the level of BPA in the tissues and to determine its dependence on the exposure dose and gender. For comparison, the same tissues were dissected from the mothers and analysed.
We report the following results: (1) the level of BPA that accumulated in a given tissue was dependent on the exposure dose; (2) the rank order of BPA accumulation in the various tissues was dependent on the gender of the offspring; (3) the average BPA concentrations in the liver and muscle of the female offspring were higher than in the males; and (4) the average BPA concentration in the central nervous system (i.e., the hindbrain and forebrain) of the male offspring was higher than in the females. (C) 2011 Elsevier B.V. All rights reserved. (literal)
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