Functional amyloids in insect immune response (Articolo in rivista)

Type
Label
  • Functional amyloids in insect immune response (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ibmb.2011.11.011 (literal)
Alternative label
  • Falabella P.; Riviello L.; Pascale M.; Di Lelio I.; Tettamanti G.; Grimaldi A.; Iannone C.; Monti M.; Pucci P.; Tamburro A.M.; Deeguileor M.; Gigliotti S.; Pennacchio F. (2012)
    Functional amyloids in insect immune response
    in Insect biochemistry and molecular biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Falabella P.; Riviello L.; Pascale M.; Di Lelio I.; Tettamanti G.; Grimaldi A.; Iannone C.; Monti M.; Pucci P.; Tamburro A.M.; Deeguileor M.; Gigliotti S.; Pennacchio F. (literal)
Pagina inizio
  • 203 (literal)
Pagina fine
  • 211 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 42 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR, Ist Genet Biofis A Buzzati Traverso, I-80131 Naples, Italy Univ Basilicata, Dipartimento Biol Difesa & Biotecnol Agroforestal, I-85100 Potenza, Italy Univ Naples Federico 2, Dipartimento Entomol & Zool Agr F Silvestri, I-80055 Naples, Italy Univ Insubria, Dipartimento Biotecnol & Sci Vita, I-21100 Varese, Italy Univ Naples Federico 2, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy (literal)
Titolo
  • Functional amyloids in insect immune response (literal)
Abstract
  • The innate immune system of insects consists of humoural and cellular responses that provide protection against invading pathogens and parasites. Defence reactions against these latter include encapsulation by immune cells and targeted melanin deposition, which is usually restricted to the surface of the foreign invader, to prevent systemic damage. Here we show that a protein produced by haemocytes of Heliothis virescens (Lepidoptera, Noctuidae) larvae, belonging to XendoU family, generates amyloid fibrils, which accumulate in large cisternae of the rough endoplasmic reticulum and are released upon immune challenge, to form a layer coating non-self objects entering the haemocoel. This amyloid layer acts as a molecular scaffold that promotes localised melanin synthesis and the adhesion of immune cells around the non-self intruder during encapsulation response. Our results demonstrate a new functional role for these protein aggregates that are commonly associated with severe human diseases. We predict that insects will offer new powerful experimental systems for studying inducible amyloidogenesis, which will likely provide fresh perspectives for its prevention. (C) 2011 Elsevier Ltd. All rights reserved. (literal)
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