miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222 (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222 (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/onc.2011.260 (literal)

Alternative label

• M Acunzo1, R Visone1, G Romano2, A Veronese1, F Lovat1, D Palmieri1,3, A Bottoni1, M Garofalo1, P Gasparini1, G Condorelli3, M Chiariello4 and CM Croce1 (2012)
  miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222
  in Oncogene (Basingstoke)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M Acunzo1, R Visone1, G Romano2, A Veronese1, F Lovat1, D Palmieri1,3, A Bottoni1, M Garofalo1, P Gasparini1, G Condorelli3, M Chiariello4 and CM Croce1 (literal)

Pagina inizio

• 634 (literal)

Pagina fine

• 642 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.nature.com/onc/journal/v31/n5/full/onc2011260a.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• Oncogene (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA; 2Fondazione IRCCS SDN, Naples, Italy; 3Department of Cellular and Molecular Biology and Pathology, Istituto di Endocrinologia e Oncologia Sperimentale 'G. Salvatore'--Consiglio Nazionale delle Ricerche, Faculty of Biotechnological Science, 'Federico II' University of Naples, Naples, Italy and 4Istituto Toscano Tumori (ITT) and Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche (IFC_CNR), Siena, Italy (literal)

Titolo

• miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222 (literal)

Abstract

• Non-small cell lung cancer (NSCLC) accounts for ~80% of all lung cancers. Although some advances in lung cancer therapy have been made, patient survival is still quite poor. Two microRNAs, miR-221 and miR-222, upregulated by the MET proto-oncogene, have been already described to enhance cell survival and to induce TNF-related apoptosis-inducing ligand (TRAIL) resistance in NSCLC cell lines, through the downregulation of p27kip1, PTEN and TIMP3. Here, we further investigated this pathway and showed that miR-130a, expressed at low level in lung cancer cell lines, by targeting MET was able to reduce TRAIL resistance in NSCLC cells through the c-Jun-mediated downregulation of miR-221 and miR-222. Moreover, we found that miR-130a reduced migratory capacity of NSCLC. A better understanding of MET-miR-221 and 222 axis regulation in drug resistance is the key in developing new strategies in NSCLC therapy. (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MARIO CHIARIELLO (Persona)
• GEROLAMA CONDORELLI (Persona)
• Dario Palmieri (Unità di personale esterno)

Incoming links:

Autore CNR di

• MARIO CHIARIELLO (Persona)
• GEROLAMA CONDORELLI (Persona)
• Dario Palmieri (Unità di personale esterno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Oncogene (Rivista)