http://www.cnr.it/ontology/cnr/individuo/prodotto/ID188996

Postnatal aversive experience impairs sensitivity to natural rewards and increases susceptibility to negative Events in Adult Life. (Articolo in rivista)

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Postnatal aversive experience impairs sensitivity to natural rewards and increases susceptibility to negative Events in Adult Life. (Articolo in rivista) (literal)

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Rossella Ventura 1,2; Roberto Coccurello 3; Diego Andolina 1,4; Emanuele Claudio Latagliata 1,4; Claudio Zanettini 3; Valentina Lampis 5; Marco Battaglia 5,6,7; Francesca R. D'Amato 3; Anna Moles 3,8 (2013)
Postnatal aversive experience impairs sensitivity to natural rewards and increases susceptibility to negative Events in Adult Life.
in Cerebral cortex (N. Y. N. Y., 1991)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Rossella Ventura 1,2; Roberto Coccurello 3; Diego Andolina 1,4; Emanuele Claudio Latagliata 1,4; Claudio Zanettini 3; Valentina Lampis 5; Marco Battaglia 5,6,7; Francesca R. D'Amato 3; Anna Moles 3,8 (literal)

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1 Santa Lucia Foundation, European Centre for Brain Research (CERC), Roma, Italy. 2 Dipartimento di Scienze e Tecnologie Biomediche, University of L'Aquila, Via Vetoio (Coppito 2) Coppito, 67100 L'Aquila, Italy. 3 Institute of Cell Biology and Neurobiology (IBCN), National Research Council (CNR)/S. Lucia Foundation, Via del Fosso di Fiorano, 64, 00143 Roma, Italy. 4 Dipartimento di Psicologia and Centro \"Daniel Bovet\", University \"La Sapienza\", Piazzale Aldo Moro 5, 00181 Roma, Italy. 5 Academic Centre for the study of Behavioral Plasticity, Vita-Salute San Raffaele University, Via S. d'Ancona 20, 20127 Milano, Italy. 6 Department of Clinical Neuroscience, Istituto Scientifico San Raffaele, 20 Via S d'Ancona, 20127 Milano, Italy. 7 Laval University, Institut Universitaire en Santé Mentale de Québec, Québec, Canada. 8 Genomnia srl Via Nerviano 31, 20020 Lainate, Milano, Italy. (literal)

Titolo

Postnatal aversive experience impairs sensitivity to natural rewards and increases susceptibility to negative Events in Adult Life. (literal)

Abstract

Evidence shows that maternal care and postnatal traumatic events can exert powerful effects on brain circuitry development but little is known about the impact of early postnatal experiences on processing of rewarding and aversive stimuli related to the medial prefrontal cortex (mpFC) function in adult life. In this study, the unstable maternal environment induced by repeated cross-fostering (RCF) impaired palatable food conditioned place preference and disrupted the natural preference for sweetened fluids in the saccharin preference test. By contrast, RCF increased sensitivity to conditioned place aversion (CPA) and enhanced immobility in the forced swimming test. Intracerebral microdialysis data showed that the RCF prevents mpFC dopamine (DA) outflow regardless of exposure to rewarding or aversive stimuli, whereas it induces a strong and sustained prefrontal norepinephrine (NE) release in response to different aversive experiences. Moreover, the selective mpFC NE depletion abolished CPA, thus indicating that prefrontal NE is required for motivational salience attribution to aversion-related stimuli. These findings demonstrate that an unstable maternal environment impairs the natural propensity to seek pleasurable sources of reward, enhances sensitivity to negative events in adult life, blunts prefrontal DA outflow, and modulates NE release in the reverse manner depending on the exposure to rewarding or aversive stimuli. (literal)

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