http://www.cnr.it/ontology/cnr/individuo/prodotto/ID188862
Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone. (Articolo in rivista)
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- Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone. (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3389/fnins.2012.00124 (literal)
- Alternative label
Farioli-Vecchioli Stefano1; Micheli Laura1; Saraulli Daniele1; Ceccarelli Manuela1,2; Cannas Sara1,2; Scardigli Raffaella3; Leonardi Luca1; Cinà Irene1; Costanzi Marco1,2; Ciotti Maria Teresa1; Moreira Pedro4; Rouault Jean-Pierre5; Cestari Vincenzo1,2; Tirone Felice1 (2012)
Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone.
in Frontiers in neuroscience (Online); Frontiers Research Foundation, Lausanne (Swaziland)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Farioli-Vecchioli Stefano1; Micheli Laura1; Saraulli Daniele1; Ceccarelli Manuela1,2; Cannas Sara1,2; Scardigli Raffaella3; Leonardi Luca1; Cinà Irene1; Costanzi Marco1,2; Ciotti Maria Teresa1; Moreira Pedro4; Rouault Jean-Pierre5; Cestari Vincenzo1,2; Tirone Felice1 (literal)
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- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431174/ (literal)
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- 1 Institute of Cell Biology and Neurobiology, National Research Council, Fondazione Santa Lucia, Rome, Italy
2 Department of Human Sciences, LUMSA University, Rome, Italy
3 Institute of Translational Pharmacology, National Research Council, Fondazione EBRI Rita Levi-Montalcini, Rome, Italy
4 Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Italy
5 Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université Lyon1, CNRS UMR 5242, INRA UMR1288, Lyon, France (literal)
- Titolo
- Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone. (literal)
- Abstract
- Btg1 belongs to a family of cell cycle inhibitory genes. We observed that Btg1 is highly
expressed in adult neurogenic niches, i.e., the dentate gyrus and subventricular zone (SVZ).
Thus, we generated Btg1 knockout mice to analyze the role of Btg1 in the process of generation
of adult new neurons. Ablation of Btg1 causes a transient increase of the proliferating
dentate gyrus stem and progenitor cells at post-natal day 7; however, at 2 months of age the
number of these proliferating cells, as well as of mature neurons, greatly decreases compared
to wild-type controls. Remarkably, adult dentate gyrus stem and progenitor cells of
Btg1-null mice exit the cell cycle after completing the S phase, express p53 and p21 at high
levels and undergo apoptosis within 5 days. In the SVZ of adult (two-month-old) Btg1-null
mice we observed an equivalent decrease, associated to apoptosis, of stem cells, neuroblasts,
and neurons; furthermore, neurospheres derived from SVZ stem cells showed
an age-dependent decrease of the self-renewal and expansion capacity.We conclude that
ablation of Btg1 reduces the pool of dividing adult stem and progenitor cells in the dentate
gyrus and SVZ by decreasing their proliferative capacity and inducing apoptosis, probably
reflecting impairment of the control of the cell cycle transition from G1 to S phase. As a
result, the ability of Btg1-null mice to discriminate among overlapping contextual memories
was affected. Btg1 appears, therefore, to be required for maintaining adult stem and
progenitor cells quiescence and self-renewal. (literal)
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