Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• C. Cinque 1,2; S. Pondiki 1,2; D. Oddi 1,2; M. G. Di Certo 1,2; S. Marinelli 1,2; A. Troisi 3; A. Moles 1,2,4; F. R. D'Amato 1,2 (2012)
  Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice
  in Translational psychiatry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• C. Cinque 1,2; S. Pondiki 1,2; D. Oddi 1,2; M. G. Di Certo 1,2; S. Marinelli 1,2; A. Troisi 3; A. Moles 1,2,4; F. R. D'Amato 1,2 (literal)

Pagina inizio

• e155 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 2 (literal)

Rivista

• Translational psychiatry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 CNR, Cell Biology and Neurobiology Institute, Roma, Italy; 2 IRCCS Santa Lucia Foundation, Roma, Italy; 3 Department of Systems Medicine, University of Rome Tor Vergata, Roma, Italy; 4 Genomnia, Linate, Italy. (literal)

Titolo

• Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice (literal)

Abstract

• Social anhedonia, or the diminished capacity to experience pleasure and reward from social affiliation, is a major symptom of different psychiatric disorders, including some forms of infantile autism and schizophrenia spectrum disorders. The brain opioid hypothesis of social attachment is a promising model for achieving insights into how neurobiological and developmental factors contribute to the regulation of social reward. In this study, genetic knocking-out and naltrexone (NTRX) treatment during the first 4 days of life were used to disrupt opioid neurotransmission in mouse pups and their attachment relationships with the mother. Both permanent (genetic) and transient (pharmacological) manipulations of opioid neurotransmission exerted long-term effects on social affiliation. When juveniles, both ?-opioid receptor knockout mice and NTRX-treated pups showed reduced interest in peers and no preference for socially rewarding environment. These results demonstrate that sociability in juvenile mice is highly dependent on the establishment during infancy of a positive affective relationship with their mothers and that opioid neurotransmission has a major role in the regulation of social hedonic capacity. If the validity of this animal model will be confirmed by future research, translational studies focusing on the interaction between early experience and opioid neurotransmission could provide useful insights for identifying endophenotypes of human psychiatric disorders associated with social anhedonia. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• FRANCESCA ROMANA D'AMATO (Persona)
• MARIA GRAZIA DI CERTO (Persona)
• ANNA MOLES (Unità di personale interno)
• SARA MARINELLI (Persona)

Insieme di parole chiave

• Keywords of "Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNA MOLES (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)
• MARIA GRAZIA DI CERTO (Persona)
• SARA MARINELLI (Persona)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Translational psychiatry (Rivista)

Insieme di parole chiave di

• Keywords of "Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice" (Insieme di parole chiave)