BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1089/neu.2011.2184 (literal)

Alternative label

• Sergio Bagnato; Luigi Minafra; Valentina Bravata; Cristina Boccagni; Antonino Sant'Angelo; Alberto Castiglione; Maria Andriolo; Lucia Francesca Lucca; Antonio De Tanti; Caterina Pistarini; Rita Formisano; Giuliano Dolce; Cecilia Gelfi; Giuseppe Galardi (2012)
  BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study.
  in Journal of neurotrauma; Mary Ann Liebert Larchmont, NY, Larchmont, NY (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sergio Bagnato; Luigi Minafra; Valentina Bravata; Cristina Boccagni; Antonino Sant'Angelo; Alberto Castiglione; Maria Andriolo; Lucia Francesca Lucca; Antonio De Tanti; Caterina Pistarini; Rita Formisano; Giuliano Dolce; Cecilia Gelfi; Giuseppe Galardi (literal)

Pagina inizio

• 2050 (literal)

Pagina fine

• 2059 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://online.liebertpub.com/doi/abs/10.1089/neu.2011.2184 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 229 (literal)

Rivista

• Journal of neurotrauma (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Unit for Severe Acquired Brain Injuries, Fondazione Istituto ''San Raffaele-G. Giglio'', Cefal§ (PA), Italy. Neurophysiology Unit, Rehabilitation Department, Fondazione Istituto ''San Raffaele-G. Giglio'', Cefal§ (PA), Italy. Clinical Pathology and Microbiology Laboratory, Fondazione Istituto ''San Raffaele-G. Giglio'', Cefal§ (PA), Italy. Laboratorio di Tecnologie Oncologiche (LATO), HSR Giglio, Cefalù (PA) , Italy. Institute of Molecular Bioimaging and Physiology (IBFM), National Council of Research (CNR), Cefalù - Segrate, Italy. Research in Advanced Neuro-Rehabilitation, Sant'Anna Institute, Crotone, Italy. Cardinal Ferrari Center, Fontanellato, Italy. IRCCS S. Maugeri Foundation, Neurorehabilitation Unit, Scientific Institute of Pavia, Pavia, Italy. Post-Coma Unit and Headache Center, IRCCS Fondazione ''Santa Lucia'' Roma, Italy. Department of Sciences and Biomedical Technologies, UNIMI, Segrate, Milan, Italy. (literal)

Titolo

• BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study. (literal)

Abstract

• Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene--BDNF Val66Met (referred to herein as BDNF(Met))--impairs cognitive function in healthy subjects. The aim of this study was to determine whether the BDNF(Met) polymorphism plays a role in the recovery of consciousness and cognitive functions in patients in a VS after a TBI. Fifty-three patients in a VS 1 month after a TBI were included in the study and genotyped for the BDNF(Met) polymorphism. Scores of levels of cognitive functioning (LCF) at 1, 3, 6, and 12 months post-TBI were retrospectively compared in patients without (Val group), and with (Met group), the BDNF(Met) polymorphism. The BDNF(Met) polymorphism was detected in 20 out of the 53 patients. The mean LCF scores in the Val and Met groups were 1.6±0.5 and 1.4±0.5 at 1 month, 2.3±0.7 and 2.5±1.2 at 3 months, 3.3±1.7 and 3.5±1.7 at 6 months, and 4±1.9 and 3.9±1.8 at 12 months, respectively (p>0.05). The percentages of patients in the Val and Met groups who emerged from the VS were 36.4% and 30% at 3 months, 66.3% and 70% at 6 months, and 70% and 87.5% at 12 months (p>0.05), respectively. These findings provide evidence that the BDNF(Met) polymorphism is not involved in cognitive improvement in patients with a VS following TBI. Future studies should focus on the role of other BDNF polymorphisms in the recovery from a VS. (literal)

Editore

• Mary Ann Liebert Larchmont, NY (Editore)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• VALENTINA BRAVATA' (Persona)
• CECILIA GELFI (Unità di personale esterno)
• LUIGI MINAFRA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• VALENTINA BRAVATA' (Persona)
• LUIGI MINAFRA (Unità di personale interno)
• CECILIA GELFI (Unità di personale esterno)

Editore di

• Mary Ann Liebert Larchmont, NY (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurotrauma (Rivista)

Insieme di parole chiave di

• Parole chiave di "BDNF (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multicentric study." (Insieme di parole chiave)